High impact information on cta

• The phenotype of embryos from homozygous cta mothers suggests that the cta gene plays a role in a signal transduction pathway used during gastrulation [1].
• In addition, we have examined the constitutive activation of cta protein by blocking GTP hydrolysis using both in vitro synthesized mutant alleles and cholera toxin treatment [2].
• Activation of the fog/cta pathway by any of these procedures results in ectopic cell shape changes in the gastrula [2].
• We have proposed that localized expression of the fog signaling protein induces apical constriction by interacting with a receptor whose downstream cellular effects are mediated by the cta G(alpha)protein. <P> In order to test this model, we have ectopically expressed fog at the blastoderm stage using an inducible promoter [2].
• We examined PEV of the heterochromatic light (lt) and concertina (cta) genes in order to investigate potential tissue or developmental differences in chromosome structure that might be informative for comparing the mechanisms of PEV of heterochromatic and euchromatic genes [3].

Analytical, diagnostic and therapeutic context of cta

• The cta gene has been cloned, and sequence analysis suggests that it encodes an alpha subunit of a G protein [1].

References