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Gene Review

Gna13  -  guanine nucleotide binding protein, alpha 13

Mus musculus

Synonyms: AU024132, AU043124, G alpha-13, G-protein subunit alpha-13, Galpha13, ...
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Disease relevance of Gna13


High impact information on Gna13

  • Disruption of the gene encoding the G protein subunit alpha13 (Galpha13) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death [6].
  • In addition, Galpha13 (-/-) embryonic fibroblasts showed greatly impaired migratory responses to thrombin [6].
  • These results demonstrate that Galpha13 participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis [6].
  • Moreover, expression of Galpha12 and Galpha13 stimulates autophosphorylation and transphosphorylation activities of Tec [7].
  • In mouse embryonic fibroblasts, the pSLIK platform was used to conditionally deplete the expression of the heterotrimeric G proteins Galpha12 and Galpha13 both singly and in combination, demonstrating the Galpha13 dependence of serum response element-mediated transcription [8].

Biological context of Gna13


Anatomical context of Gna13


Associations of Gna13 with chemical compounds


Physical interactions of Gna13


Regulatory relationships of Gna13


Other interactions of Gna13


Analytical, diagnostic and therapeutic context of Gna13

  • Northern blots of multiple clones revealed the expression of a 1.8-kilobase pair mutant Galpha13 transcript in transfected cells, in addition to the 6-kilobase pair endogenous mRNA [21].
  • The transfection resulted in a doubling of the expression of Galpha13 protein in these cells as assessed by Western blot analysis [21].
  • The interaction was demonstrated by (i) the binding of G alpha 13 to immobilized beta gamma-complexes and (ii) the formation of stable heterotrimers during sucrose-density-gradient centrifugation [27].


  1. Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid. Jho, E.H., Malbon, C.C. J. Biol. Chem. (1997) [Pubmed]
  2. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. Radhika, V., Onesime, D., Ha, J.H., Dhanasekaran, N. J. Biol. Chem. (2004) [Pubmed]
  3. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Kelly, P., Moeller, B.J., Juneja, J., Booden, M.A., Der, C.J., Daaka, Y., Dewhirst, M.W., Fields, T.A., Casey, P.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. Krawetz, R., Mackenzie, M.J., Sun, Q., Walton, P.A., Kelly, G.M. Exp. Cell Res. (2006) [Pubmed]
  5. Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. McGrew, L., Chang, M.S., Sanders-Bush, E. Mol. Pharmacol. (2002) [Pubmed]
  6. Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Offermanns, S., Mancino, V., Revel, J.P., Simon, M.I. Science (1997) [Pubmed]
  7. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. Mao, J., Xie, W., Yuan, H., Simon, M.I., Mano, H., Wu, D. EMBO J. (1998) [Pubmed]
  8. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Shin, K.J., Wall, E.A., Zavzavadjian, J.R., Santat, L.A., Liu, J., Hwang, J.I., Rebres, R., Roach, T., Seaman, W., Simon, M.I., Fraser, I.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells. Kanungo, J., Wang, H.Y., Malbon, C.C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. Essential role for Galpha13 in endothelial cells during embryonic development. Ruppel, K.M., Willison, D., Kataoka, H., Wang, A., Zheng, Y.W., Cornelissen, I., Yin, L., Xu, S.M., Coughlin, S.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein. Profirovic, J., Gorovoy, M., Niu, J., Pavlovic, S., Voyno-Yasenetskaya, T. J. Biol. Chem. (2005) [Pubmed]
  12. G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation. Lee, Y.N., Malbon, C.C., Wang, H.Y. J. Biol. Chem. (2004) [Pubmed]
  13. Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation. Gohla, A., Offermanns, S., Wilkie, T.M., Schultz, G. J. Biol. Chem. (1999) [Pubmed]
  14. G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. Buhl, A.M., Johnson, N.L., Dhanasekaran, N., Johnson, G.L. J. Biol. Chem. (1995) [Pubmed]
  15. Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4. Wang, H.Y., Kanungo, J., Malbon, C.C. J. Biol. Chem. (2002) [Pubmed]
  16. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Mao, J., Yuan, H., Xie, W., Wu, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways. Katoh, H., Aoki, J., Yamaguchi, Y., Kitano, Y., Ichikawa, A., Negishi, M. J. Biol. Chem. (1998) [Pubmed]
  18. Inhibition of nitric oxide synthase activity and nitric oxide-dependent calcium influx in renal epithelial cells by cyclic adenosine monophosphate: implications for cell injury. Kitamura, K., Tomita, K., Miller, R.T. J. Am. Soc. Nephrol. (1997) [Pubmed]
  19. Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. Obara, Y., Kurose, H., Nakahata, N. Mol. Pharmacol. (2005) [Pubmed]
  20. Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator. Chen, Z., Singer, W.D., Sternweis, P.C., Sprang, S.R. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  21. The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. Liu, J.L., Blakesley, V.A., Gutkind, J.S., LeRoith, D. J. Biol. Chem. (1997) [Pubmed]
  22. Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells. Vara Prasad, M.V., Shore, S.K., Dhanasekaran, N. Oncogene (1994) [Pubmed]
  23. The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. Gohla, A., Harhammer, R., Schultz, G. J. Biol. Chem. (1998) [Pubmed]
  24. G alpha q and G alpha 13 regulate NHE-1 and intracellular calcium in epithelial cells. Kitamura, K., Singer, W.D., Cano, A., Miller, R.T. Am. J. Physiol. (1995) [Pubmed]
  25. The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. Liu, B., Wu, D. J. Biol. Chem. (2003) [Pubmed]
  26. Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Galpha13 signaling. Liu, G., Voyno-Yasenetskaya, T.A. J. Biol. Chem. (2005) [Pubmed]
  27. Purification of the G-protein G13 from rat brain membranes. Harhammer, R., Nürnberg, B., Spicher, K., Schultz, G. Biochem. J. (1994) [Pubmed]
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