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Gene Review:

cdc28 - hypothetical protein

Schizosaccharomyces pombe 972h-

This record was discontinued.

Shimada, M. et al., Beach, D. et al., Sudbery, P.E. et al.

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High impact information on cdc28

It is concluded that the cdc 2 and cdc 28 genes perform homologous cell cycle control functions in the two organisms [1].
A functionally homologous sequence which complements the cdc 2 mutation has also been isolated from a Saccharomyces cerevisiae gene bank and this sequence has been shown to contain the cdc 28 cell cycle start gene of S. cerevisiae [1].
Hartwell and his colleagues have shown such a point in G1 phase in the budding yeast, Saccharomyces cerevisiae, defined by the cdc 28 mutation [2].
A search for mutants of cdc28 cells that enter mitosis with unspliced RNA resulted in the identification of an orb5 point mutant [3].
Overexpression of the major B-type cyclin Cdc13p induced cdc28 cells to enter mitosis [3].

Biological context of cdc28

Screening of cdc mutants of fission yeast for those whose cell cycle arrest is independent of the DNA damage checkpoint identified the RNA splicing-deficient cdc28 mutant [3].

References

Functionally homologous cell cycle control genes in budding and fission yeast. Beach, D., Durkacz, B., Nurse, P. Nature (1982) [Pubmed]
Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Sudbery, P.E., Goodey, A.R., Carter, B.L. Nature (1980) [Pubmed]
Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. Shimada, M., Namikawa-Yamada, C., Nakanishi, M., Murakami, H. J. Biol. Chem. (2005) [Pubmed]

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