The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

crm1  -  importin family nuclear export receptor Crm1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on crm1

  • The fission yeast crm1 mutant was defective in the nuclear export of NES-fused proteins, but not in the import of nuclear localization signal (NLS)-fused proteins [1].
  • In fission yeasts, the nuclear accumulation of mRNA also occurred in cells treated with LMB or in a temperature-sensitive crm1 mutant at a restrictive temperature [2].
  • The increase of hba2 expression was independent of the pap1 transcription factor which is repressed by wild type crm1 [3].
  • Examination of hba2 expression determined that this gene is overexpressed in mutant strains resistant to brefeldin A due to mutations in the negative regulator crm1 (bar1) gene or the bar2 gene [3].
  • We have isolated novel caffeine-resistant mutants of S. pombe which define three distinct genes caf2, caf3 and caf4 [4].


  1. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo, N., Wolff, B., Sekimoto, T., Schreiner, E.P., Yoneda, Y., Yanagida, M., Horinouchi, S., Yoshida, M. Exp. Cell Res. (1998) [Pubmed]
  2. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast. Watanabe, M., Fukuda, M., Yoshida, M., Yanagida, M., Nishida, E. Genes Cells (1999) [Pubmed]
  3. Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance. Turi, T.G., Rose, J.K. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko, Z., Miklos, I., Carr, A.M., Sipiczki, M. Curr. Genet. (1997) [Pubmed]
WikiGenes - Universities