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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

crm1  -  importin family nuclear export receptor Crm1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on crm1

  • The fission yeast crm1 mutant was defective in the nuclear export of NES-fused proteins, but not in the import of nuclear localization signal (NLS)-fused proteins [1].
  • In fission yeasts, the nuclear accumulation of mRNA also occurred in cells treated with LMB or in a temperature-sensitive crm1 mutant at a restrictive temperature [2].
  • The increase of hba2 expression was independent of the pap1 transcription factor which is repressed by wild type crm1 [3].
  • Examination of hba2 expression determined that this gene is overexpressed in mutant strains resistant to brefeldin A due to mutations in the negative regulator crm1 (bar1) gene or the bar2 gene [3].
  • We have isolated novel caffeine-resistant mutants of S. pombe which define three distinct genes caf2, caf3 and caf4 [4].

References

  1. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo, N., Wolff, B., Sekimoto, T., Schreiner, E.P., Yoneda, Y., Yanagida, M., Horinouchi, S., Yoshida, M. Exp. Cell Res. (1998) [Pubmed]
  2. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast. Watanabe, M., Fukuda, M., Yoshida, M., Yanagida, M., Nishida, E. Genes Cells (1999) [Pubmed]
  3. Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance. Turi, T.G., Rose, J.K. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko, Z., Miklos, I., Carr, A.M., Sipiczki, M. Curr. Genet. (1997) [Pubmed]
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