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Gene Review

Xpo1  -  exportin 1, CRM1 homolog (yeast)

Mus musculus

Synonyms: AA420417, Chromosome region maintenance 1 protein homolog, Crm1, Exp1, Exportin-1
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Disease relevance of Xpo1

  • Epstein-Barr virus EB2 protein exports unspliced RNA via a Crm-1-independent pathway [1].
  • A reporter vector developed from the 3' end of the MMTV provirus was Rem responsive and required both the presence of the MMTV env-U3 junction and a functional Crm1 pathway [2].

High impact information on Xpo1

  • In contrast, La, which is a nuclear phosphoprotein, undergoes nucleocytoplasmic shuttling independent of the nuclear export protein Crm1 [3].
  • Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 [4].
  • These data indicate that in smooth muscle, stimulation of Ca2+-dependent, calcineurin-mediated nuclear import and suppression of Crm-1/JNK-dependent nuclear export are both required for induction of NFATc3 nuclear accumulation [5].
  • The defect in production of MVMi ssDNA in fibroblasts can also be overcome by introducing a mutation in MVMi NS2 that enhances its interaction with Crm1 [6].
  • Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity [7].

Biological context of Xpo1


Anatomical context of Xpo1


Associations of Xpo1 with chemical compounds

  • These data show that the nuclear export pathway used by steroid hormone receptors such as GR is distinct from the Crm1 pathway [9].
  • The CLS directed leptomycin B-sensitive nuclear export of reporter proteins, suggesting its dependence on the nuclear exporter Crm1/exportin 1 [10].
  • In Exp 2, the OB-LN difference of Exp 1 was decreased by giving naltrexone (10 mg/kg sc) before LiCl, which suggested opiate involvement [11].
  • In Exp 1, healthy OB formed stronger CTAs than LN to a saccharin taste paired with lithium chloride (LiCl, 3 mEq/kg ip) [11].
  • In Exp 1, following the oral IGF-I administration, serum IGF-I concentration increased at hour 4 (p<0.01) and returned to the hour 0 level by hour 8, whereas glucose concentration was lowest at hour 4 and returned to the hour 0 level by hour 16 [12].


  1. Epstein-Barr virus EB2 protein exports unspliced RNA via a Crm-1-independent pathway. Farjot, G., Buisson, M., Duc Dodon, M., Gazzolo, L., Sergeant, A., Mikaelian, I. J. Virol. (2000) [Pubmed]
  2. Mouse mammary tumor virus encodes a self-regulatory RNA export protein and is a complex retrovirus. Mertz, J.A., Simper, M.S., Lozano, M.M., Payne, S.M., Dudley, J.P. J. Virol. (2005) [Pubmed]
  3. Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. Fok, V., Friend, K., Steitz, J.A. J. Cell Biol. (2006) [Pubmed]
  4. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. Suzuki, H., Tashiro, S., Hira, S., Sun, J., Yamazaki, C., Zenke, Y., Ikeda-Saito, M., Yoshida, M., Igarashi, K. EMBO J. (2004) [Pubmed]
  5. Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1. Gomez, M.F., Bosc, L.V., Stevenson, A.S., Wilkerson, M.K., Hill-Eubanks, D.C., Nelson, M.T. J. Biol. Chem. (2003) [Pubmed]
  6. Replication of minute virus of mice DNA is critically dependent on accumulated levels of NS2. Choi, E.Y., Newman, A.E., Burger, L., Pintel, D. J. Virol. (2005) [Pubmed]
  7. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. Shinmura, K., Tarapore, P., Tokuyama, Y., George, K.R., Fukasawa, K. FEBS Lett. (2005) [Pubmed]
  8. Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Knauer, S.K., Carra, G., Stauber, R.H. Mol. Cell. Biol. (2005) [Pubmed]
  9. Ca2+-dependent nuclear export mediated by calreticulin. Holaska, J.M., Black, B.E., Rastinejad, F., Paschal, B.M. Mol. Cell. Biol. (2002) [Pubmed]
  10. Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element. Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M., Igarashi, K. J. Biol. Chem. (2000) [Pubmed]
  11. Propensity to form conditioned taste aversions augments anorexia in obese (ob/ob) mice with B16 melanoma. Thompson, C.I., Margules, D.L., Kreider, J.W., Boha, S.P., Rejer, R.E., Quirey, R.A., Reitz, J.A. Behav. Neurosci. (1993) [Pubmed]
  12. Effects of oral administration of insulin-like growth factor-I on circulating concentration of insulin-like growth factor-I and growth of internal organs in weanling mice. Kim, W.K., Ryu, Y.H., Seo, D.S., Lee, C.Y., Ko, Y. Biol. Neonate (2006) [Pubmed]
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