Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

FCGRT - Fc fragment of IgG, receptor, transporter,...

Bos taurus

Clawson, M.L. et al., Laegreid, W.W. et al.

Laegreid, Heaton, Keen, Grosse, Chitko-McKown, Smith, Keele, Bennett, Besser, Clawson, Heaton, Chitko-McKown, Fox, Smith, Snelling, Keele, Laegreid,

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High impact information on FCGRT

A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FCGRT) and beta-2-microglobulin ( B2M) [1].
Previously, two FCGRT haplotypes were associated with differences in immunoglobulin G (IgG) passive transfer in cattle (Laegreid et al. (2002) Mamm Genome 13, 704-710) [1].
These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study [2].
Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population [2].

Biological context of FCGRT

Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves [2].
These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality [2].

References

Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves. Clawson, M.L., Heaton, M.P., Chitko-McKown, C.G., Fox, J.M., Smith, T.P., Snelling, W.M., Keele, J.W., Laegreid, W.W. Mamm. Genome (2004) [Pubmed]
Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves. Laegreid, W.W., Heaton, M.P., Keen, J.E., Grosse, W.M., Chitko-McKown, C.G., Smith, T.P., Keele, J.W., Bennett, G.L., Besser, T.E. Mamm. Genome (2002) [Pubmed]

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