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Gene Review

FCGRT  -  Fc fragment of IgG, receptor, transporter,...

Bos taurus

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High impact information on FCGRT

  • A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FCGRT) and beta-2-microglobulin ( B2M) [1].
  • Previously, two FCGRT haplotypes were associated with differences in immunoglobulin G (IgG) passive transfer in cattle (Laegreid et al. (2002) Mamm Genome 13, 704-710) [1].
  • These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study [2].
  • Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population [2].

Biological context of FCGRT


  1. Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves. Clawson, M.L., Heaton, M.P., Chitko-McKown, C.G., Fox, J.M., Smith, T.P., Snelling, W.M., Keele, J.W., Laegreid, W.W. Mamm. Genome (2004) [Pubmed]
  2. Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves. Laegreid, W.W., Heaton, M.P., Keen, J.E., Grosse, W.M., Chitko-McKown, C.G., Smith, T.P., Keele, J.W., Bennett, G.L., Besser, T.E. Mamm. Genome (2002) [Pubmed]
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