Gene Review:
FCGRT - Fc fragment of IgG, receptor, transporter,...
Homo sapiens
Synonyms:
FCRN, FcRn, IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, Neonatal Fc receptor, ...
- Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Wani, M.A., Haynes, L.D., Kim, J., Bronson, C.L., Chaudhury, C., Mohanty, S., Waldmann, T.A., Robinson, J.M., Anderson, C.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn. Praetor, A., Hunziker, W. J. Cell. Sci. (2002)
- The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Cianga, P., Cianga, C., Cozma, L., Ward, E.S., Carasevici, E. Hum. Immunol. (2003)
- The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. Akilesh, S., Petkova, S., Sproule, T.J., Shaffer, D.J., Christianson, G.J., Roopenian, D. J. Clin. Invest. (2004)
- Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. Li, N., Zhao, M., Hilario-Vargas, J., Prisayanh, P., Warren, S., Diaz, L.A., Roopenian, D.C., Liu, Z. J. Clin. Invest. (2005)
- Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Ghetie, V., Ward, E.S. Annu. Rev. Immunol. (2000)
- A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Lencer, W.I., Blumberg, R.S. Trends Cell Biol. (2005)
- The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. Kandil, E., Egashira, M., Miyoshi, O., Niikawa, N., Ishibashi, T., Kasahara, M., Miyosi, O. Cytogenet. Cell Genet. (1996)
- Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport. Leach, J.L., Sedmak, D.D., Osborne, J.M., Rahill, B., Lairmore, M.D., Anderson, C.L. J. Immunol. (1996)
- Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Ober, R.J., Martinez, C., Lai, X., Zhou, J., Ward, E.S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. Ober, R.J., Martinez, C., Vaccaro, C., Zhou, J., Ward, E.S. J. Immunol. (2004)
- MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. Zhu, X., Meng, G., Dickinson, B.L., Li, X., Mizoguchi, E., Miao, L., Wang, Y., Robert, C., Wu, B., Smith, P.D., Lencer, W.I., Blumberg, R.S. J. Immunol. (2001)
- The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Zhu, X., Peng, J., Raychowdhury, R., Nakajima, A., Lencer, W.I., Blumberg, R.S. Biochem. J. (2002)
- Overexpression of the human neonatal Fc-receptor alpha-chain in trophoblast-derived BeWo cells increases cellular retention of beta2-microglobulin. Ellinger, I., Reischer, H., Lehner, C., Leitner, K., Hunziker, W., Fuchs, R. Placenta (2005)
- Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Raghavan, M., Chen, M.Y., Gastinel, L.N., Bjorkman, P.J. Immunity (1994)
- Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Yoshida, M., Claypool, S.M., Wagner, J.S., Mizoguchi, E., Mizoguchi, A., Roopenian, D.C., Lencer, W.I., Blumberg, R.S. Immunity (2004)
- Chimeric human-mouse IgG antibodies with shuffled constant region exons demonstrate that multiple domains contribute to in vivo half-life. Zuckier, L.S., Chang, C.J., Scharff, M.D., Morrison, S.L. Cancer Res. (1998)
- Membrane-anchored human FcRn can oligomerize in the absence of IgG. Praetor, A., Jones, R.M., Wong, W.L., Hunziker, W. J. Mol. Biol. (2002)
- Co-localization of the neonatal Fc gamma receptor and IgG in human placental term syncytiotrophoblasts. Kristoffersen, E.K., Matre, R. Eur. J. Immunol. (1996)
- Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. Claypool, S.M., Dickinson, B.L., Yoshida, M., Lencer, W.I., Blumberg, R.S. J. Biol. Chem. (2002)
- Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG. Liu, X., Ye, L., Bai, Y., Mojidi, H., Simister, N.E., Zhu, X. J. Immunol. (2008)
- Current concepts in mucosal immunity. II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function. Blumberg, R.S. Am. J. Physiol. (1998)
- Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Martin, W.L., West, A.P., Gan, L., Bjorkman, P.J. Mol. Cell (2001)
- From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. Ward, E.S., Martinez, C., Vaccaro, C., Zhou, J., Tang, Q., Ober, R.J. Mol. Biol. Cell (2005)
- Molecular comparisons of the beta 2-microglobulin-binding site in class I major-histocompatibility-complex alpha-chains and proteins of related sequences. Tysoe-Calnon, V.A., Grundy, J.E., Perkins, S.J. Biochem. J. (1991)
- Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. Zhu, X., Peng, J., Chen, D., Liu, X., Ye, L., Iijima, H., Kadavil, K., Lencer, W.I., Blumberg, R.S. J. Immunol. (2005)
- Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. Schilling, R., Ijaz, S., Davidoff, M., Lee, J.Y., Locarnini, S., Williams, R., Naoumov, N.V. J. Virol. (2003)
- Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. Zhou, J., Mateos, F., Ober, R.J., Ward, E.S. J. Mol. Biol. (2005)
- Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,). West, A.P., Bjorkman, P.J. Biochemistry (2000)