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Gene Review

Fcgrt  -  Fc receptor, IgG, alpha chain transporter

Mus musculus

Synonyms: FcRn, Fcrn, IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, Neonatal Fc receptor, ...
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Disease relevance of Fcgrt


High impact information on Fcgrt


Biological context of Fcgrt

  • Phylogenetic tree analysis suggested that, like the MICA, AZGP1, and CD1 genes, the Fcrn gene diverged from MHC class I genes after the emergence of amphibians but before the split of placental and marsupial mammals [6].
  • We report hat mice lacking the transporter associated with antigen presentation (TAP-/-) were also resistant to disease, whereas CD1-/- and CD8-/- mice were susceptible; susceptibility also did not correlate with neonatal Fc receptor or HEPH expression [7].
  • Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates [8].

Anatomical context of Fcgrt


Other interactions of Fcgrt

  • The 5'-flanking region of the Fcrn gene contained the binding motifs for two cytokine-inducible transcription factors, NF-IL6 and NF1 [6].
  • The studies indicate that the neonatal Fc receptor, FcRn, is involved in transcytosis across both yolk sac and neonatal intestine in addition to the regulation of IgG catabolism [14].

Analytical, diagnostic and therapeutic context of Fcgrt

  • Sequence analysis of the Fcrn gene isolated from eight mouse strains showed that the membrane-distal domain of FcRn has at least three amino acid variants [6].
  • Consistent with this result, Southern blot analysis with a mouse Fcrn cDNA probe detected cross-hybridizing bands in various mammalian species and chickens [6].


  1. The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus. Velin, D., Acha-Orbea, H., Kraehenbuhl, J.P. J. Virol. (1996) [Pubmed]
  2. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. Yoshida, M., Kobayashi, K., Kuo, T.T., Bry, L., Glickman, J.N., Claypool, S.M., Kaser, A., Nagaishi, T., Higgins, D.E., Mizoguchi, E., Wakatsuki, Y., Roopenian, D.C., Mizoguchi, A., Lencer, W.I., Blumberg, R.S. J. Clin. Invest. (2006) [Pubmed]
  3. Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice. Karlsson, M.C., Wernersson, S., Diaz de Ståhl, T., Gustavsson, S., Heyman, B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Vidarsson, G., Stemerding, A.M., Stapleton, N.M., Spliethoff, S.E., Janssen, H., Rebers, F.E., de Haas, M., van de Winkel, J.G. Blood (2006) [Pubmed]
  5. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. Datta-Mannan, A., Witcher, D.R., Tang, Y., Watkins, J., Wroblewski, V.J. J. Biol. Chem. (2007) [Pubmed]
  6. Structural and phylogenetic analysis of the MHC class I-like Fc receptor gene. Kandil, E., Noguchi, M., Ishibashi, T., Kasahara, M. J. Immunol. (1995) [Pubmed]
  7. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Singer, D.S., Zinger, H., Kohn, L.D., Mozes, E. Eur. J. Immunol. (1999) [Pubmed]
  8. Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates. Datta-Mannan, A., Witcher, D.R., Tang, Y., Watkins, J., Jiang, W., Wroblewski, V.J. Drug Metab. Dispos. (2007) [Pubmed]
  9. Functional analysis of the mouse Fcgrt 5' proximal promoter. Tiwari, B., Junghans, R.P. Biochim. Biophys. Acta (2005) [Pubmed]
  10. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. Israel, E.J., Patel, V.K., Taylor, S.F., Marshak-Rothstein, A., Simister, N.E. J. Immunol. (1995) [Pubmed]
  11. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Zhu, X., Peng, J., Raychowdhury, R., Nakajima, A., Lencer, W.I., Blumberg, R.S. Biochem. J. (2002) [Pubmed]
  12. Cloning and analysis of the gene encoding the human neonatal Fc receptor. Mikulska, J.E., Pablo, L., Canel, J., Simister, N.E. Eur. J. Immunogenet. (2000) [Pubmed]
  13. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. Deane, R., Sagare, A., Hamm, K., Parisi, M., LaRue, B., Guo, H., Wu, Z., Holtzman, D.M., Zlokovic, B.V. J. Neurosci. (2005) [Pubmed]
  14. Localization of the site of the IgG molecule that regulates maternofetal transmission in mice. Medesan, C., Radu, C., Kim, J.K., Ghetie, V., Ward, E.S. Eur. J. Immunol. (1996) [Pubmed]
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