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Gene Review

Gdi  -  GDP dissociation inhibitor

Drosophila melanogaster

Synonyms: CG4422, Dmel\CG4422, GDI, GdI, N7-3, ...
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Disease relevance of Gdi

  • Both rat Rab GDI alpha and beta proteins expressed in Escherichia coli showed a similar degree of activity of regulating the GDP/GTP exchange reaction to that of bovine Rab GDI using Rab3A and Rab11 as substrates [1].

High impact information on Gdi


Biological context of Gdi


Anatomical context of Gdi

  • An activity partially purified from yeast cytosol dissociates GDP-bound Sec4 from yeast membranes, suggesting that yeast also possess a GDI protein that functions to recycle Sec4 from its target membrane [5].

Analytical, diagnostic and therapeutic context of Gdi


  1. Molecular cloning and characterization of two rab GDI species from rat brain: brain-specific and ubiquitous types. Nishimura, N., Nakamura, H., Takai, Y., Sano, K. J. Biol. Chem. (1994) [Pubmed]
  2. Return of the GDI: the GoLoco motif in cell division. Willard, F.S., Kimple, R.J., Siderovski, D.P. Annu. Rev. Biochem. (2004) [Pubmed]
  3. A Drosophila homolog of bovine smg p25a GDP dissociation inhibitor undergoes a shift in isoelectric point in the developmental mutant quartet. Zahner, J.E., Cheney, C.M. Mol. Cell. Biol. (1993) [Pubmed]
  4. Drosophila rab GDI mutants disrupt development but have normal Rab membrane extraction. Ricard, C.S., Jakubowski, J.M., Verbsky, J.W., Barbieri, M.A., Lewis, W.M., Fernandez, G.E., Vogel, M., Tsou, C., Prasad, V., Stahl, P.D., Waksman, G., Cheney, C.M. Genesis (2001) [Pubmed]
  5. Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity. Garrett, M.D., Kabcenell, A.K., Zahner, J.E., Kaibuchi, K., Sasaki, T., Takai, Y., Cheney, C.M., Novick, P.J. FEBS Lett. (1993) [Pubmed]
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