The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GDI1  -  GDP dissociation inhibitor 1

Homo sapiens

Synonyms: 1A, FLJ41411, GDI-1, GDIL, Guanosine diphosphate dissociation inhibitor 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GDI1


Psychiatry related information on GDI1


High impact information on GDI1


Biological context of GDI1


Anatomical context of GDI1

  • In the infected cells RhoA was dissociated from guanine nucleotide dissociation inhibitor-1 (GDI-1) and accumulated as a monomeric protein in the cytosol, whereas Rac and CDC42Hs remained GDI-bound [12].

Associations of GDI1 with chemical compounds


Physical interactions of GDI1

  • PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1 [15].

Other interactions of GDI1


Analytical, diagnostic and therapeutic context of GDI1

  • The Northern blot analysis and in situ hybridization to sections of mouse embryos and postnatal tissues have revealed that the rab GDI alpha/XAP-4 is expressed predominantly in neural and sensory tissues and may thus serve a specific function in neural signal transmission [18].


  1. Molecular study of the PAK3 and GDI1 genes in nonsyndromic X-linked mental retardation spanish patients. Rifé, M., Mallolas, J., Castellví-Bel, S., Badenas, C., Jiménez, D., Milà, M. Am. J. Med. Genet. (2000) [Pubmed]
  2. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. D'Adamo, P., Menegon, A., Lo Nigro, C., Grasso, M., Gulisano, M., Tamanini, F., Bienvenu, T., Gedeon, A.K., Oostra, B., Wu, S.K., Tandon, A., Valtorta, F., Balch, W.E., Chelly, J., Toniolo, D. Nat. Genet. (1998) [Pubmed]
  3. Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. Pylypenko, O., Rak, A., Durek, T., Kushnir, S., Dursina, B.E., Thomae, N.H., Constantinescu, A.T., Brunsveld, L., Watzke, A., Waldmann, H., Goody, R.S., Alexandrov, K. EMBO J. (2006) [Pubmed]
  4. Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI. Rivero, F., Illenberger, D., Somesh, B.P., Dislich, H., Adam, N., Meyer, A.K. EMBO J. (2002) [Pubmed]
  5. A gene for dominant nonspecific X-linked mental retardation is located in Xq28. des Portes, V., Billuart, P., Carrié, A., Bachner, L., Bienvenu, T., Vinet, M.C., Beldjord, C., Ponsot, G., Kahn, A., Boué, J., Chelly, J. Am. J. Hum. Genet. (1997) [Pubmed]
  6. Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor. Bienvenu, T., des Portes, V., Saint Martin, A., McDonell, N., Billuart, P., Carrié, A., Vinet, M.C., Couvert, P., Toniolo, D., Ropers, H.H., Moraine, C., van Bokhoven, H., Fryns, J.P., Kahn, A., Beldjord, C., Chelly, J. Hum. Mol. Genet. (1998) [Pubmed]
  7. Evaluation of two X chromosomal candidate genes for Rett syndrome: glutamate dehydrogenase-2 (GLUD2) and rab GDP-dissociation inhibitor (GDI1). Wan, M., Francke, U. Am. J. Med. Genet. (1998) [Pubmed]
  8. GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein. Chuang, T.H., Xu, X., Knaus, U.G., Hart, M.J., Bokoch, G.M. J. Biol. Chem. (1993) [Pubmed]
  9. GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis. Essmann, F., Wieder, T., Otto, A., Müller, E.C., Dörken, B., Daniel, P.T. Biochem. J. (2000) [Pubmed]
  10. Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI). Sedlacek, Z., Konecki, D.S., Korn, B., Klauck, S.M., Poustka, A. Mamm. Genome (1994) [Pubmed]
  11. A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28. Hamel, B.C., Kremer, H., Wesby-van Swaay, E., van den Helm, B., Smits, A.P., Oostra, B.A., Ropers, H.H., Mariman, E.C. Am. J. Med. Genet. (1996) [Pubmed]
  12. Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells. Aepfelbacher, M., Trasak, C., Wilharm, G., Wiedemann, A., Trulzsch, K., Krauss, K., Gierschik, P., Heesemann, J. J. Biol. Chem. (2003) [Pubmed]
  13. Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion. Kowluru, A., Veluthakal, R. Diabetes (2005) [Pubmed]
  14. Identification of genes regulated by memantine and MK-801 in adult rat brain by cDNA microarray analysis. Marvanová, M., Lakso, M., Wong, G. Neuropsychopharmacology (2004) [Pubmed]
  15. PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. Hutt, D.M., Da-Silva, L.F., Chang, L.H., Prosser, D.C., Ngsee, J.K. J. Biol. Chem. (2000) [Pubmed]
  16. Localization of human X chromosomal mental retardation (MRX) genes in chicken and comparison with the chicken genome sequence data. Kohn, M., Kehrer-Sawatzki, H., Hameister, H. Cytogenet. Genome Res. (2005) [Pubmed]
  17. The amphioxus rab GDP-dissociation inhibitor (GDI) gene is neural-specific: implications for the evolution of chordate rab GDI genes. Sedlacek, Z., Shimeld, S.M., Münstermann, E., Poustka, A. Mol. Biol. Evol. (1999) [Pubmed]
  18. Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. Bächner, D., Sedlacek, Z., Korn, B., Hameister, H., Poustka, A. Hum. Mol. Genet. (1995) [Pubmed]
WikiGenes - Universities