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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

me31B  -  maternal expression at 31B

Drosophila melanogaster

Synonyms: CG4916, DDX6, Dhh1p/Me31b, DmRH3, Dmel\CG4916, ...
 
 
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Disease relevance of me31B

  • Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma [1].
 

High impact information on me31B

  • A search for mutations in the ME31B gene has established that the P element which causes the female-sterile mutation flipper lies in the 3' flank of the ME31B gene [2].
  • We have termed this gene ME31B to reflect its maternal (ovarian germ-line) expression and its location within the 31B chromosome region [2].
  • ME31B is a developmentally regulated gene that is expressed preferentially in the female germline and may be required for oogenesis [3].

References

  1. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Lu, D., Yunis, J.J. Nucleic Acids Res. (1992) [Pubmed]
  2. A second maternally expressed Drosophila gene encodes a putative RNA helicase of the "DEAD box" family. de Valoir, T., Tucker, M.A., Belikoff, E.J., Camp, L.A., Bolduc, C., Beckingham, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe. Maekawa, H., Nakagawa, T., Uno, Y., Kitamura, K., Shimoda, C. Mol. Gen. Genet. (1994) [Pubmed]
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