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Gene Review:

IFNA7 - interferon, alpha 7

Homo sapiens

Synonyms: IFN-alpha-7, IFN-alpha-J1, IFN-alphaJ, IFNA-J, Interferon alpha-7, ...

Langer, J.A. et al., Goetze, S. et al., Sperber, S.J. et al., Shafferman, A. et al., Ortaldo, J.R. et al., et al.

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Disease relevance of IFNA7

Several E. coli trp expression plasmids were constructed for efficient transcription and translation of the mature IFN-alpha J1 [1].
The 50% inhibitory concentration against HIV was 37 +/- 14 pg/ml for IFN-alpha A, and ranged from 15 +/- 3 pg/ml for IFN-alpha J/C(Fnu4HI) to > 90,000 pg/ml for IFN-alpha D [2].

High impact information on IFNA7

IFN-alpha J appeared to interact with receptors for IFN on NK cells since it was found to interfere with the boosting of NK activity by other species of IFN-alpha [3].
The promoters of the IFNA10 and the IFNA7 genes have a moderate approximately 20% binding affinity to the nuclear matrix; the termination sequences show stronger association (70-80%) under our standardized conditions [4].
To verify and further refine the biomathematical methods, we focus on a 10 kb region in the cluster with the pseudogene IFNWP18 and the interferon alpha genes IFNA10 and IFNA7 [4].
We demonstrate here directly that IFN-alpha J can bind to NK cells and can compete with [125I]IFN-alpha A for binding sites [5].
It has previously been shown that recombinant DNA-derived human leukocyte interferon IFN-alpha J, which is active on human cells in antiviral and antiproliferative assays, substantially lacks the ability of other purified leukocyte IFN (e.g., IFN-alpha A) to enhance natural killer (NK) activity [5].

Associations of IFNA7 with chemical compounds

Genetic engineering of human interferons from lymphoblastoid cells: II. Construction of trp expression plasmids and their use for efficient expression of IFN-alpha J1 [6].

Other interactions of IFNA7

Regulation of natural killer cytotoxicity by recombinant alpha interferons. Augmentation by IFN-alpha 7, an interferon similar to IFN-alpha J [7].

Analytical, diagnostic and therapeutic context of IFNA7

Recombinant IFN-alpha J was least effective in inhibiting CA24 in human conjunctival cell cultures [8].
Genetic engineering of human interferons from lymphoblastoid cells: III. Purification, physicochemical and biological properties of bacterial IFN-alpha J1 [9].

References

Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. Cohen, S., Velan, B., Grosfeld, H., Shalita, Z., Leitner, M., Shafferman, A. Dev. Biol. Stand. (1985) [Pubmed]
Anti-HIV-1 activity of recombinant and hybrid species of interferon-alpha. Sperber, S.J., Gocke, D.J., Haberzettl, C., Kuk, R., Schwartz, B., Pestka, S. J. Interferon Res. (1992) [Pubmed]
A species of human alpha interferon that lacks the ability to boost human natural killer activity. Ortaldo, J.R., Herberman, R.B., Harvey, C., Osheroff, P., Pan, Y.C., Kelder, B., Pestka, S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
Computational and in vitro analysis of destabilized DNA regions in the interferon gene cluster: potential of predicting functional gene domains. Goetze, S., Gluch, A., Benham, C., Bode, J. Biochemistry (2003) [Pubmed]
Binding of human alpha-interferons to natural killer cells. Langer, J.A., Ortaldo, J.R., Pestka, S. J. Interferon Res. (1986) [Pubmed]
Genetic engineering of human interferons from lymphoblastoid cells: II. Construction of trp expression plasmids and their use for efficient expression of IFN-alpha J1. Shafferman, A., Cohen, S., Grosfeld, H., Leitner, M., Velan, B. Adv. Biotechnol. Processes (1985) [Pubmed]
Regulation of natural killer cytotoxicity by recombinant alpha interferons. Augmentation by IFN-alpha 7, an interferon similar to IFN-alpha J. Platsoucas, C.D., Fox, F.E., Oleszak, E., Fong, K., Nanno, M., Ioannides, C.G., Trotta, P.P. Anticancer Res. (1989) [Pubmed]
Inhibition of epidemic isolates of coxsackievirus type A 24 by recombinant and natural interferon alpha and interferon beta. Langford, M.P., Kadi, R.M., Ganley, J.P., Yin-Murphy, M. Intervirology (1988) [Pubmed]
Genetic engineering of human interferons from lymphoblastoid cells: III. Purification, physicochemical and biological properties of bacterial IFN-alpha J1. Grosfeld, H., Cohen, S., Velan, B., Shafferman, A. Adv. Biotechnol. Processes (1985) [Pubmed]

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