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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genetic Engineering

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Disease relevance of Genetic Engineering


High impact information on Genetic Engineering


Chemical compound and disease context of Genetic Engineering


Biological context of Genetic Engineering


Anatomical context of Genetic Engineering


Associations of Genetic Engineering with chemical compounds


Gene context of Genetic Engineering

  • We found that both of these genetic interventions produced a several-fold increase in the lifespan of Lama2(-/-) mice [31].
  • Truncation of signal transducer and activator of transcription (STAT) 5 at the carboxy-terminal domain, either by genetic engineering or by proteolytic cleavage, results in generation of dominant-negative forms [32].
  • We have now used genetic engineering to introduce these residues into mouse MT-1 [33].
  • Genetic engineering of these cells to express hCD152-hCD59, a chimeric molecule designed to block CD86 in cis, was accompanied by a reduction in susceptibility to human NK cell-mediated cytotoxicity [34].
  • The cloning of PKD1 and PKD2 in recent years has provided the initial steps in defining the mechanisms underlying renal cyst formation in this condition, with the aim of defining pharmacological and genetic interventions that may ameliorate the diverse and often serious clinical manifestations of this disease [35].

Analytical, diagnostic and therapeutic context of Genetic Engineering


  1. Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition. Patel, K., Piagentini, M., Rascher, A., Tian, Z.Q., Buchanan, G.O., Regentin, R., Hu, Z., Hutchinson, C.R., McDaniel, R. Chem. Biol. (2004) [Pubmed]
  2. Human cystatin A is inactivated by engineered truncation. The NH2-terminal region of the cysteine proteinase inhibitor is essential for expression of its inhibitory activity. Shibuya, K., Kaji, H., Itoh, T., Ohyama, Y., Tsujikami, A., Tate, S., Takeda, A., Kumagai, I., Hirao, I., Miura, K. Biochemistry (1995) [Pubmed]
  3. SH1 (cysteine 717) of smooth muscle myosin: its role in motor function. Kojima, S., Fujiwara, K., Onishi, H. Biochemistry (1999) [Pubmed]
  4. Ethanol synthesis by genetic engineering in cyanobacteria. Deng, M.D., Coleman, J.R. Appl. Environ. Microbiol. (1999) [Pubmed]
  5. Increased production of zeaxanthin and other pigments by application of genetic engineering techniques to Synechocystis sp. strain PCC 6803. Lagarde, D., Beuf, L., Vermaas, W. Appl. Environ. Microbiol. (2000) [Pubmed]
  6. Selenocysteine. Stadtman, T.C. Annu. Rev. Biochem. (1996) [Pubmed]
  7. Identification of a Brazil-nut allergen in transgenic soybeans. Nordlee, J.A., Taylor, S.L., Townsend, J.A., Thomas, L.A., Bush, R.K. N. Engl. J. Med. (1996) [Pubmed]
  8. Overexpression of beta-carotene hydroxylase enhances stress tolerance in Arabidopsis. Davison, P.A., Hunter, C.N., Horton, P. Nature (2002) [Pubmed]
  9. Genetic engineering. TNF production licensed. Dickman, S. Nature (1991) [Pubmed]
  10. Genetic engineering. Tryptophan under suspicion. Gershon, D. Nature (1990) [Pubmed]
  11. Role of variant prealbumin in the pathogenesis of familial amyloidotic polyneuropathy: fate of normal and variant prealbumin in the circulation. Ando, Y., Ikegawa, S., Miyazaki, A., Inoue, M., Morino, Y., Araki, S. Arch. Biochem. Biophys. (1989) [Pubmed]
  12. The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers--a review and hypothesis. Becker, Y. Virus Genes (2004) [Pubmed]
  13. Microbial formation, biotechnological production and applications of 1,2-propanediol. Bennett, G.N., San, K.Y. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  14. Generation of new epothilones by genetic engineering of a polyketide synthase in Myxococcus xanthus. Tang, L., Chung, L., Carney, J.R., Starks, C.M., Licari, P., Katz, L. J. Antibiot. (2005) [Pubmed]
  15. Mechanism of cardiac fibrosis by angiotensin. New insight revealed by genetic engineering. Matsusaka, T., Katori, H., Homma, T., Ichikawa, I. Trends Cardiovasc. Med. (1999) [Pubmed]
  16. Plasmid RP4 as a vector replicor in genetic engineering. Jacob, A.E., Grinter, N.J. Nature (1975) [Pubmed]
  17. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Peitz, M., Pfannkuche, K., Rajewsky, K., Edenhofer, F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  18. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Talley, A.K., Dewhurst, S., Perry, S.W., Dollard, S.C., Gummuluru, S., Fine, S.M., New, D., Epstein, L.G., Gendelman, H.E., Gelbard, H.A. Mol. Cell. Biol. (1995) [Pubmed]
  19. A single-chain bifunctional gonadotropin analog is secreted from Chinese hamster ovary cells as two distinct bioactive species. Garcia-Campayo, V., Jablonka-Shariff, A., Boime, I. J. Biol. Chem. (2004) [Pubmed]
  20. Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. Catalano, A., Rodilossi, S., Rippo, M.R., Caprari, P., Procopio, A. J. Biol. Chem. (2004) [Pubmed]
  21. Prevention of type 1 diabetes by gene therapy. Tian, C., Bagley, J., Cretin, N., Seth, N., Wucherpfennig, K.W., Iacomini, J. J. Clin. Invest. (2004) [Pubmed]
  22. A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments. Chang, H.C., Bao, Z., Yao, Y., Tse, A.G., Goyarts, E.C., Madsen, M., Kawasaki, E., Brauer, P.P., Sacchettini, J.C., Nathenson, S.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  23. The erythropoietin receptor of rat erythroid progenitor lens. Characterization and affinity cross-linkage. Mayeux, P., Billat, C., Jacquot, R. J. Biol. Chem. (1987) [Pubmed]
  24. Modulation of GvHD by suicide-gene transduced donor T lymphocytes: clinical applications in mismatched transplantation. Ciceri, F., Bonini, C., Gallo-Stampino, C., Bordignon, C. Cytotherapy. (2005) [Pubmed]
  25. Neoplasms of the mediastinum, chest wall, and pleura. Chang, A.Y. Current opinion in oncology. (1994) [Pubmed]
  26. Genetic engineering patents. Contest in prospect over interferon rights. Beardsley, T. Nature (1985) [Pubmed]
  27. Osmoprotective compounds in the Plumbaginaceae: a natural experiment in metabolic engineering of stress tolerance. Hanson, A.D., Rathinasabapathi, B., Rivoal, J., Burnet, M., Dillon, M.O., Gage, D.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  28. Caffeine: a well known but little mentioned compound in plant science. Ashihara, H., Crozier, A. Trends Plant Sci. (2001) [Pubmed]
  29. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Stevenson-Paulik, J., Bastidas, R.J., Chiou, S.T., Frye, R.A., York, J.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  30. Structure-function analysis with tissue-type plasminogen activator. Effect of deletion of NH2-terminal domains on its biochemical and biological properties. Kalyan, N.K., Lee, S.G., Wilhelm, J., Fu, K.P., Hum, W.T., Rappaport, R., Hartzell, R.W., Urbano, C., Hung, P.P. J. Biol. Chem. (1988) [Pubmed]
  31. Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy. Girgenrath, M., Dominov, J.A., Kostek, C.A., Miller, J.B. J. Clin. Invest. (2004) [Pubmed]
  32. Calpain is a signal transducer and activator of transcription (STAT) 3 and STAT5 protease. Oda, A., Wakao, H., Fujita, H. Blood (2002) [Pubmed]
  33. Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1. Romero-Isart, N., Jensen, L.T., Zerbe, O., Winge, D.R., Vasak, M. J. Biol. Chem. (2002) [Pubmed]
  34. Human NK cell-mediated cytotoxicity triggered by CD86 and Gal alpha 1,3-Gal is inhibited in genetically modified porcine cells. Costa, C., Barber, D.F., Fodor, W.L. J. Immunol. (2002) [Pubmed]
  35. The polycystins: a novel class of membrane-associated proteins involved in renal cystic disease. Sandford, R., Mulroy, S., Foggensteiner, L. Cell. Mol. Life Sci. (1999) [Pubmed]
  36. Corticotropin-releasing hormone and animal models of anxiety: gene-environment interactions. Bakshi, V.P., Kalin, N.H. Biol. Psychiatry (2000) [Pubmed]
  37. Synthesis of green fluorescent protein-ricin and monitoring of its intracellular trafficking. Tagge, E., Harris, B., Burbage, C., Hall, P., Vesely, J., Willingham, M., Frankel, A. Bioconjug. Chem. (1997) [Pubmed]
  38. Thiol-directed immobilization of recombinant IgG-binding receptors. Ljungquist, C., Jansson, B., Moks, T., Uhlén, M. Eur. J. Biochem. (1989) [Pubmed]
  39. Can we genetically engineer safer and more effective immunotherapy reagents? Westritschnig, K., Valenta, R. Current opinion in allergy and clinical immunology. (2003) [Pubmed]
  40. Can enhancement be distinguished from prevention in genetic medicine? Juengst, E.T. The Journal of medicine and philosophy. (1997) [Pubmed]
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