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Gene Review: 

Lrr47  -  Leucine-rich repeat 47

Drosophila melanogaster

Synonyms: CG6098, CT19173, Dmel\CG6098, LRR47, Lrr-47
 
 
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High impact information on Lrr47

  • LRR47 belongs to a subfamily of LRR proteins that have in common the ability to interact with ras GTPase [1].
  • In this paper the 5' flanking region of the LRR47 gene is described and the initiation point for the maternal transcription unit is defined [1].
  • These results suggest that LRR47 function may be modulated in the cell or nuclear division cycle [1].
  • Whole-mount in situ hybridization studies show that the LRR47 transcript is uniformly distributed in early cleavage embryos but becomes depleted at the termini by the blastoderm stage [1].
  • Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of Drosophila [2].
 

Biological context of Lrr47

  • The transcript of the LRR47 gene is detected in adult females and in early embryogenesis [2].
  • The LRR47 gene maps to position 32A on the left arm of chromosome 2, an interval in which three genes with semi-lethal maternal effects (dal, hup and wdl) are located [2].
 

Analytical, diagnostic and therapeutic context of Lrr47

  • In Western blot experiments, a protein of approx. 47 kDa, which is expressed in a similar developmental profile and purifies in peripheral membrane protein extracts, is detected by an antibody specific for LRR47 [2].

References

  1. Promoter sequence and expression of the leucine-rich repeat gene LRR47: evidence for cytoplasmic and nuclear localization in Drosophila embryos and cells. Buchanan, S.G., Dornan, S., Gay, N.J. Gene (1998) [Pubmed]
  2. Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of Drosophila. Ntwasa, M., Buchanan, S.G., Gay, N.J. Biochim. Biophys. Acta (1994) [Pubmed]
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