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Gene Review

DGAT2L6  -  diacylglycerol O-acyltransferase 2-like 6

Homo sapiens

Synonyms: DC3, Diacylglycerol O-acyltransferase 2-like protein 6, Diacylglycerol O-acyltransferase candidate 3, FLJ25989, hDC3
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Disease relevance of DGAT2L6

  • Moreover, uncommitted T cells that encounter the CS-induced DC3 develop into Th2-biased cells, which may additionally decrease the Th1-mediated tissue damage but, on the other hand, Th2 cytokines may promote undesirable elevation of IgE and eosinophilia [1].
  • The pathogenesis of nontropical sprue is determined by both genetic factors, demonstrated with a strong association with certain HLA haplotypes (B8, DR3, DR7 and DC3) and presumably also environmental events (virus infection?), which render the mucosa susceptible to gluten [2].

High impact information on DGAT2L6

  • Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta [3].
  • The DC-3 beta gene, corresponding to a polymorphic restriction fragment, was cloned and sequenced and found to exist in five exons spanning 8 kilobase pairs of DNA [3].
  • Examination of mucosal biopsies obtained from both central (level I) and subsegmental (level II) bronchi showed that the highest number of CD45-, DC3-, DC4-, and CD8-positive cells were found in the group with asthma [4].
  • Sixty patients with celiac disease were typed by radioimmunoassay for the specificities HLA-DR3, HLA-DR7, and for an allelic specificity, DC3, of the HLA-associated DC locus [5].
  • The previously described associations with DR3, DR7, B8, B13, and A1 can be explained by decreasing degrees of linkage disequilibrium with DC3 [5].


  1. Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3. de Jong, E.C., Vieira, P.L., Kalinski, P., Kapsenberg, M.L. J. Leukoc. Biol. (1999) [Pubmed]
  2. The sprue syndromes. Westergaard, H. Am. J. Med. Sci. (1985) [Pubmed]
  3. Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta. Boss, J.M., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  4. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Azzawi, M., Bradley, B., Jeffery, P.K., Frew, A.J., Wardlaw, A.J., Knowles, G., Assoufi, B., Collins, J.V., Durham, S., Kay, A.B. Am. Rev. Respir. Dis. (1990) [Pubmed]
  5. Evidence that celiac disease is primarily associated with a DC locus allelic specificity. Tosi, R., Vismara, D., Tanigaki, N., Ferrara, G.B., Cicimarra, F., Buffolano, W., Follo, D., Auricchio, S. Clin. Immunol. Immunopathol. (1983) [Pubmed]
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