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Gene Review

tam  -  tamas

Drosophila melanogaster

Synonyms: 34Dc, AAC47658, BG:DS00941.6, CG8987, D-pol gamma-alpha, ...
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High impact information on tam

  • The tam mutation reduces the transcription of a repressor gene, extramacrochaetae, and causes enlargement of a proneural cluster where supernumerary precursor cells emerge, resulting in extra mechanosensory organs in the fly [1].
  • In this study, we report the isolation and analysis of the tamou (tam) gene that encodes a cell-cell junction-associated protein, which is homologous to mammalian ZO-1, a member of the membrane-associated guanylate kinase homolog family [1].
  • Both subunits have been cloned and characterized in a variety of model systems, and genetic mutants of the catalytic subunit were first identified in Drosophila, as chemically induced mutations that disrupt larval behavior (tamas) [2].
  • DNA polymerase gamma, Pol gamma, is the key replicative enzyme in animal mitochondria [2].
  • The DNA polymerase is inhibited by 200 mM NaCl and is unable to use poly(rA)/oligo(dT) as a template, thus differentiating it from DNA polymerase gamma [3].

Biological context of tam


Anatomical context of tam

  • The polypeptide is properly targeted to mitochondria, yet the large excess of pol gamma-alpha does not interfere with mtDNA replication under these conditions where the endogenous polypeptide is apparently present in amounts that exceed of the demand for its function in the cell [5].

Other interactions of tam


Analytical, diagnostic and therapeutic context of tam

  • In striking contrast, overexpression of pol gamma-alpha at the same level in transgenic flies interferes with the mtDNA replication process, presumably by altering the mechanism of DNA synthesis, suggesting differential requirements for, and/or regulation of, mtDNA replication in Drosophila cell culture versus the developing organism [5].


  1. The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1. Takahisa, M., Togashi, S., Suzuki, T., Kobayashi, M., Murayama, A., Kondo, K., Miyake, T., Ueda, R. Genes Dev. (1996) [Pubmed]
  2. The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster. Iyengar, B., Luo, N., Farr, C.L., Kaguni, L.S., Campos, A.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. DNA polymerase delta from embryos of Drosophila melanogaster. Chiang, C.S., Mitsis, P.G., Lehman, I.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. The tamas gene, identified as a mutation that disrupts larval behavior in Drosophila melanogaster, codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-gamma125). Iyengar, B., Roote, J., Campos, A.R. Genetics (1999) [Pubmed]
  5. Overexpression of the catalytic subunit of DNA polymerase gamma results in depletion of mitochondrial DNA in Drosophila melanogaster. Lefai, E., Calleja, M., Ruiz de Mena, I., Lagina, A.T., Kaguni, L.S., Garesse, R. Mol. Gen. Genet. (2000) [Pubmed]
  6. Stimulation of Drosophila mitochondrial DNA polymerase by single-stranded DNA-binding protein. Williams, A.J., Kaguni, L.S. J. Biol. Chem. (1995) [Pubmed]
  7. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Ropp, P.A., Copeland, W.C. Genomics (1996) [Pubmed]
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