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Gene Review

RpA-70  -  Replication Protein A 70

Drosophila melanogaster

Synonyms: CG9633, D-RPA70, D-SSB, DRP-A, DmRPA, ...
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Disease relevance of RpA-70

  • Mitochondrial DNA polymerase from Drosophila embryos has been characterized with regard to its mechanism of DNA synthesis in the presence of single-stranded DNA-binding protein from Escherichia coli [1].

High impact information on RpA-70


Biological context of RpA-70

  • Strikingly, in ovaries a relatively large amount of DRP-A was observed during the early mitotic stages of oogenesis [4].
  • In contrast to other systems where a phosphorylated form of RP-A has been correlated with S phase, only the nonphosphorylated form of Drosophila RP-A is observed in early Drosophila embryos during DNA replication [4].
  • Subsequently at mitosis, DRP-A becomes delocalized [4].
  • Replication protein A (RP-A) is an essential single-stranded DNA binding protein (SSB) involved in the initiation and elongation phases of eukaryotic DNA replication [5].
  • After this point, dm-RPA70 expression is downregulated in cells that enter a G1 phase and exit the mitotic cycle, becoming restricted to brief bursts of accumulation from late G1 to S phase [6].

Regulatory relationships of RpA-70


Analytical, diagnostic and therapeutic context of RpA-70

  • Equilibrium titrations indicate that D-SSB binds with low cooperativity, omega = 10-300, and high apparent affinity, K omega = (0.7-5) x 10(7) M-1, at 225 mM NaCl [7].


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