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Gene Review

POLN  -  polymerase (DNA directed) nu

Homo sapiens

Synonyms: DNA polymerase nu
 
 
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Disease relevance of POLN

  • POLN has a processivity of DNA synthesis (1-100 nucleotides) similar to the exonuclease-deficient Klenow fragment of E. coli pol I, is inhibited by dideoxynucleotides, and resistant to aphidicolin [1].
 

High impact information on POLN

  • Furthermore, POLN can perform translesion synthesis past thymine glycol, a common endogenous and radiation-induced product of reactive oxygen species damage to DNA [1].
  • Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol [1].
  • Expression analysis by northern blotting and in situ hybridization showed highest expression of full-length POLN in human and mouse testis [2].
  • The region starting from residue 419 shares 33% identity (48% similarity) with the equivalent region of Escherichia coli DNA polymerase I. POLN is expressed in human cell lines with numerous alternatively spliced transcripts, and a full-length human coding region that comprises 24 exons within 160 kilobases of genomic DNA [2].
  • POLN localized to the nucleus when expressed as a enhanced green fluorescent protein (GFP)-tagged protein in human fibroblasts [2].
 

Biological context of POLN

References

  1. Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Takata, K., Shimizu, T., Iwai, S., Wood, R.D. J. Biol. Chem. (2006) [Pubmed]
  2. POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. Marini, F., Kim, N., Schuffert, A., Wood, R.D. J. Biol. Chem. (2003) [Pubmed]
 
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