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Gene Review

Gp210  -  Gp210 ortholog (H. sapiens)

Drosophila melanogaster

Synonyms: CG14467, CG7897, Dm gp210, Dmel\CG7897, GP210, ...
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Disease relevance of gp210


High impact information on gp210

  • These chromatin-attached vesicles contained lamin Dm and otefin but not gp210 [2].
  • Drosophila gp210, an invertebrate nuclear pore complex glycoprotein [3].
  • Results of developmental studies demonstrated that like nuclear lamin and DNA topoisomerase II, gp210 is found abundantly in nonnuclear form early in embryogenesis where it presumably fuels the rapid assembly of new nuclei [3].
  • We have established a stable, continuous culture Drosophila Schneider 2 cell line that efficiently expresses a secreted, truncated form of the HIV envelope gp120 protein in a regulated manner [4].
  • The Drosophila produced recombinant gp120 protein is highly glycosylated, is recognized by gp120-specific monoclonal antibodies, binds to the CD4 receptor and has the ability to inhibit syncytia formation between uninfected CD4+ cells and HIV infected cells [4].

Anatomical context of gp210

  • These results have implications for understanding the regulation of higher eukaryotic nuclear pore complex behavior through development as well as for determining gp210 function genetically [3].


  1. The N-terminal 31 amino acids of human immunodeficiency virus type 1 envelope protein gp120 contain a potential gp41 contact site. Ivey-Hoyle, M., Clark, R.K., Rosenberg, M. J. Virol. (1991) [Pubmed]
  2. Nuclear membrane vesicle targeting to chromatin in a Drosophila embryo cell-free system. Ulitzur, N., Harel, A., Goldberg, M., Feinstein, N., Gruenbaum, Y. Mol. Biol. Cell (1997) [Pubmed]
  3. Drosophila gp210, an invertebrate nuclear pore complex glycoprotein. Berrios, M., Meller, V.H., McConnell, M., Fisher, P.A. Eur. J. Cell Biol. (1995) [Pubmed]
  4. Regulated expression allows high level production and secretion of HIV-1 gp120 envelope glycoprotein in Drosophila Schneider cells. Culp, J.S., Johansen, H., Hellmig, B., Beck, J., Matthews, T.J., Delers, A., Rosenberg, M. Biotechnology (N.Y.) (1991) [Pubmed]
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