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Gene Review

NUP210  -  nucleoporin 210kDa

Homo sapiens

Synonyms: FLJ22389, GP210, KIAA0906, Nuclear envelope pore membrane protein POM 210, Nuclear pore membrane glycoprotein 210, ...
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Disease relevance of NUP210


High impact information on NUP210

  • We previously identified a 210,000-mol-wt platelet glycoprotein (GP 210) that is missing from Bernard-Soulier platelets, and found that an antibody against GP 210 inhibits ristocetin-induced platelet agglutination [2].
  • Conversely, anti-GP 210 antiserum and F(ab)2 fragments inhibited binding of fluorescein-labeled Fc fragments to intact platelets [2].
  • Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans [3].
  • Therefore, WT1 is probably not regulating GP210 expression [1].
  • BACKGROUND: Glycoprotein 210 (GP210) is a transmembrane component of the nuclear pore complex of metazoans, with a short carboxyterminus protruding towards the cytoplasm [1].

Biological context of NUP210


Anatomical context of NUP210

  • The specialized immunoglobulin (Ig) domain in the globular tail of the animal lamins, and the Ig domains in the nuclear membrane protein GP210 are shown to be related to distinct prokaryotic families of Ig domains [4].

Analytical, diagnostic and therapeutic context of NUP210

  • We now show by immunoblotting that GP 210 binds heat-aggregated rabbit and human IgG, as well as keyhole limpet hemocyanin (KLH)-anti-KLH and ovalbumin (OA)-anti-OA immune complexes [2].


  1. Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210. Olsson, M., English, M.A., Mason, J., Licht, J.D., Ekblom, P. Journal of negative results in biomedicine [electronic resource]. (2004) [Pubmed]
  2. Evidence that a 210,000-molecular-weight glycoprotein (GP 210) serves as a platelet Fc receptor. Stricker, R.B., Reyes, P.T., Corash, L., Shuman, M.A. J. Clin. Invest. (1987) [Pubmed]
  3. Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. Cohen, M., Feinstein, N., Wilson, K.L., Gruenbaum, Y. Mol. Biol. Cell (2003) [Pubmed]
  4. Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex. Mans, B.J., Anantharaman, V., Aravind, L., Koonin, E.V. Cell Cycle (2004) [Pubmed]
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