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Gene Review

wun  -  wunen

Drosophila melanogaster

Synonyms: CG8804, Dmel\CG8804, Germ cell guidance factor, LPP-like, Phosphatidic acid phosphatase type 2, ...
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High impact information on wun

  • The Drosophila protein Wunen repels migrating germ cells [1].
  • Wunen shows strong similarity to the enzyme type 2 phosphatidic acid phophatase (PAP2)4, suggesting that it is involved in lipid metabolism [1].
  • Wunen can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm [1].
  • For example, migrating germ cells compete with the surrounding somatic tissue for the substrate of the lipid phosphate phosphatases encoded by the genes Wunen and Wunen2 [2].
  • In somatic cells, Wun and Wun2 may provide a repulsive environment for pole cell migration by depleting this extracellular substrate [3].

Biological context of wun

  • Wun and Wun2 also affect the viability of pole cells, because overexpression of either one in somatic cells causes pole cell death [3].
  • RESULTS: We present evidence that Wunen dimerises, that these associations require the last thirty-five C-terminal amino-acids and depend upon the presence of an intact catalytic site [4].
  • Wunen, a Drosophila LPP homologue, has been shown to play a pivotal role in primordial germ cell (PGC) migration and survival during embryogenesis [4].

Anatomical context of wun

  • Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo [5].
  • Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2 [5].

Associations of wun with chemical compounds


Other interactions of wun

  • In contrast, Scrib1 synthesis in pole cells required contact with gonadal mesodermal cells as revealed by the absence of Scrib1 in wunen or tinman-zinc finger homeodomain-1 pseudo-gonads made only of aggregated pole cells [8].


  1. The Drosophila protein Wunen repels migrating germ cells. Zhang, N., Zhang, J., Purcell, K.J., Cheng, Y., Howard, K. Nature (1997) [Pubmed]
  2. The social lives of migrating cells in Drosophila. Montell, D.J. Curr. Opin. Genet. Dev. (2006) [Pubmed]
  3. Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos. Hanyu-Nakamura, K., Kobayashi, S., Nakamura, A. Development (2004) [Pubmed]
  4. Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity. Burnett, C., Makridou, P., Hewlett, L., Howard, K. BMC Biochem. (2004) [Pubmed]
  5. Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2. Sano, H., Renault, A.D., Lehmann, R. J. Cell Biol. (2005) [Pubmed]
  6. Cell migration in Drosophila. Forbes, A., Lehmann, R. Curr. Opin. Genet. Dev. (1999) [Pubmed]
  7. Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases. Zhang, N., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Gridley, T. Genomics (2000) [Pubmed]
  8. Requirements for scribble expression in newly formed gonads of Drosophila embryos. Marhold, J., Papagiannouli, F., Li, M., Patel, A., Mechler, B.M. Gene Expr. Patterns (2003) [Pubmed]
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