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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dare  -  defective in the avoidance of repellents

Drosophila melanogaster

Synonyms: AR, Adrenodoxin reductase, CG12390, Dare, Dmel\CG12390, ...
 
 
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Disease relevance of dare

 

High impact information on dare

  • In mammals, AR plays a key role in the synthesis of all steroid hormones [2].
  • The 0.98 electrophoretic allele is associated with The TL, SC, CH and PP gene arrangements, while the 1.00 electrophoretic allele is characteristic of the AR and ST gene arrangements [3].
  • All six yeast AR-like open reading frames (ORFs) have been cloned into plasmid expression vectors [1].
  • Using BLAST searches against the human AR gene sequence, we identified six genes in the complete S. cerevisiae genome with strong homology to AR [1].
  • Ongoing studies are aimed at characterizing the phenotypes of yeast strains containing single and multiple knockouts of the AR-like genes [1].

References

  1. Functional genomic studies of aldo-keto reductases. Petrash, J.M., Murthy, B.S., Young, M., Morris, K., Rikimaru, L., Griest, T.A., Harter, T. Chem. Biol. Interact. (2001) [Pubmed]
  2. The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Freeman, M.R., Dobritsa, A., Gaines, P., Segraves, W.A., Carlson, J.R. Development (1999) [Pubmed]
  3. Activity variants of acid phosphatase-3 among chromosome 3 inversions of Drosophila pseudoobscura. Norman, R.A., Prakash, S. Genetics (1980) [Pubmed]
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