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Fdxr  -  ferredoxin reductase

Mus musculus

Synonyms: AR, Adrenodoxin reductase, Ferredoxin reductase, Ferredoxin--NADP(+) reductase, NADPH:adrenodoxin oxidoreductase, mitochondrial
 
 
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Disease relevance of Fdxr

  • Results suggest that target organs of diabetic complications, such as the kidney, lens, and retina are sensitive to damage associated with a high level of AR expression, but other organs are not; the susceptibility of each organ to diabetic complications is determined by not only hAR but also other factors [1].
 

High impact information on Fdxr

 

Biological context of Fdxr

  • A cDNA encoding ferredoxin reductase has been isolated from a mouse kidney cDNA library using human ferredoxin reductase cDNA as a probe [6].
  • cDNA fragments encoding mouse ferredoxin and ferredoxin reductase were simultaneously introduced into COS7 cells by using an expression vector, pUC-SR alpha plasmid [7].
 

Associations of Fdxr with chemical compounds

  • Week 5 cecal AR (DCA, BCA, DBA), NR (DCA), and DC (DCA, DBA) activities were reduced [8].
  • To evaluate the temporal relationship between AR signaling and cardiac remodeling, we studied the effects of controlled overexpression of the A1-AR using a cardiac-specific and tetracycline-transactivating factor-regulated promoter [9].
 

Other interactions of Fdxr

 

Analytical, diagnostic and therapeutic context of Fdxr

References

  1. Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Yamaoka, T., Nishimura, C., Yamashita, K., Itakura, M., Yamada, T., Fujimoto, J., Kokai, Y. Diabetologia (1995) [Pubmed]
  2. Adrenocorticotropic hormone increases specific proteins of the mitochondrial fraction that are translated inside or outside this organelle in cultured adrenal tumor cells. Ray, D.B., Horst, I.A., Kowal, J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  3. Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney. Lee, H.W., Kim, W.Y., Song, H.K., Yang, C.W., Han, K.H., Kwon, H.M., Kim, J. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  4. Androgens differentially potentiate mouse intestinal smooth muscle by nongenomic activation of polyamine synthesis and rho kinase activation. Gonz??lez-Montelongo, M.C., Mar??n, R., G??mez, T., D??az, M. Endocrinology (2006) [Pubmed]
  5. 7-Deoxydaunomycinone quinone methide reactivity with thiol nucleophiles. Ramakrishnan, K., Fisher, J. J. Med. Chem. (1986) [Pubmed]
  6. cDNA cloning of mouse ferredoxin reductase from kidney. Itoh, S., Iemura, O., Yamada, E., Yoshimura, T., Tsujikawa, K., Kohama, Y., Mimura, T. Biochim. Biophys. Acta (1995) [Pubmed]
  7. Simultaneous expression of ferredoxin, ferredoxin reductase and P450 in COS7 cells. Itoh, S., Iemura, O., Yoshimura, T., Tsujikawa, K., Yamada, E., Nonaka, Y., Okamoto, M., Mimura, T., Kohama, Y. Biochim. Biophys. Acta (1997) [Pubmed]
  8. The disinfection by-products dichloro-, dibromo-, and bromochloroacetic acid impact intestinal microflora and metabolism in Fischer 344 rats upon exposure in drinking water. George, S.E., Nelson, G.M., Swank, A.E., Brooks, L.R., Bailey, K., George, M., DeAngelo, A. Toxicol. Sci. (2000) [Pubmed]
  9. Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Funakoshi, H., Chan, T.O., Good, J.C., Libonati, J.R., Piuhola, J., Chen, X., MacDonnell, S.M., Lee, L.L., Herrmann, D.E., Zhang, J., Martini, J., Palmer, T.M., Sanbe, A., Robbins, J., Houser, S.R., Koch, W.J., Feldman, A.M. Circulation (2006) [Pubmed]
  10. Transcriptional regulation of the CYP11A1 and ferredoxin genes. Chung, B.C., Guo, I.C., Chou, S.J. Steroids (1997) [Pubmed]
  11. Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced form of sheep ferredoxin reductase. Furukawa, A., Okuyama, E., Sumi, T., Ichikawa, Y. Biol. Reprod. (1997) [Pubmed]
 
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