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Gene Review:

ALS9 - agglutinin-like protein; entire contig...

Candida albicans SC5314

Zhao, X. et al., Xu, Z. et al.

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High impact information on ALS9

The ALS gene family of Candida albicans consists of eight genes (ALS1 to ALS7 and ALS9) that encode cell-wall glycoproteins involved in adhesion to host surfaces [1].
Data from the C. albicans genome sequencing project provided the first indication that strain SC5314 encoded two divergent ALS9-like sequences and that three of the ALS genes (ALS5, ALS1 and ALS9) were contiguous on chromosome 6 [1].
Furthermore, the up-regulation of EFG1, CPH2, TEC1, CDC24, SAP10, ALS9, SNF1, SPO72 and BDF1, and the down-regulation of RAD32, IPF3636 and UBI4 resulted in stronger virulence and invasiveness in the resistant isolates compared with susceptible ones [2].

Analytical, diagnostic and therapeutic context of ALS9

Data from PCR analysis and construction of both single and double deletion mutants indicated that the divergent sequences were alleles of ALS9, and located downstream of ALS5 and ALS1 [1].

References

Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9. Zhao, X., Pujol, C., Soll, D.R., Hoyer, L.L. Microbiology (Reading, Engl.) (2003) [Pubmed]
cDNA array analysis of the differential expression change in virulence-related genes during the development of resistance in Candida albicans. Xu, Z., Cao, Y.B., Zhang, J.D., Cao, Y.Y., Gao, P.H., Wang, D.J., Fu, X.P., Ying, K., Chen, W.S., Jiang, Y.Y. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]

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