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Gene Review:

JUND - jun D proto-oncogene

Homo sapiens

Synonyms: AP-1, Transcription factor jun-D

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Disease relevance of JUND

Here we show that RHA recognizes a structured 5'-terminal post-transcriptional control element (PCE) of a retrovirus and the JUND growth-control gene [1].
Decreased transcription factor junD in brains of patients with Down syndrome [2].

High impact information on JUND

Using a yeast two-hybrid screen with menin as the bait, we have identified the transcription factor JunD as a direct menin-interacting partner [3].
VBP does not heterodimerize with B-ZIP domains from C/EBP alpha, JUND, or FOS [4].
In addition, diminished Ret-9bp autophosphorylation led to reduced phosphorylation of the transcription factor jun-D [5].
Altered genes in high-grade tumours were related to cell cycle (cyclin-dependent kinase 4) and transcription (jun d proto-oncogene) [6].
PDE4C-containing cosmids also contained the genes for the growth regulatory transcription factor, JUND, and the mini guanine nucleotide regulatory protein, RAB3A [7].

Biological context of JUND

The RAB3A gene was shown to consist of 5 exons spanning 7.9 kb, while the JUND gene was found to contain no introns [7].
Assignment of rat Jun family genes to chromosome 19 (Junb), chromosome 5q31-33 (Jun), and chromosome 16 (Jund) [8].

Associations of JUND with chemical compounds

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND [7].

References

RNA helicase A is necessary for translation of selected messenger RNAs. Hartman, T.R., Qian, S., Bolinger, C., Fernandez, S., Schoenberg, D.R., Boris-Lawrie, K. Nat. Struct. Mol. Biol. (2006) [Pubmed]
Decreased transcription factor junD in brains of patients with Down syndrome. Labudova, O., Krapfenbauer, K., Moenkemann, H., Rink, H., Kitzmüller, E., Cairns, N., Lubec, G. Neurosci. Lett. (1998) [Pubmed]
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Agarwal, S.K., Guru, S.C., Heppner, C., Erdos, M.R., Collins, R.M., Park, S.Y., Saggar, S., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Marx, S.J., Burns, A.L. Cell (1999) [Pubmed]
Attractive interhelical electrostatic interactions in the proline- and acidic-rich region (PAR) leucine zipper subfamily preclude heterodimerization with other basic leucine zipper subfamilies. Moll, J.R., Olive, M., Vinson, C. J. Biol. Chem. (2000) [Pubmed]
Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1. Hennige, A.M., Lammers, R., Höppner, W., Arlt, D., Strack, V., Teichmann, R., Machicao, F., Ullrich, A., Häring, H.U., Kellerer, M. Endocrinology (2001) [Pubmed]
Gene expression profiling of noninvasive primary urothelial tumours using microarrays. Aaboe, M., Marcussen, N., Jensen, K.M., Thykjaer, T., Dyrskjøt, L., Orntoft, T.F. Br. J. Cancer (2005) [Pubmed]
Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. Sullivan, M., Olsen, A.S., Houslay, M.D. Cell. Signal. (1999) [Pubmed]
Assignment of rat Jun family genes to chromosome 19 (Junb), chromosome 5q31-33 (Jun), and chromosome 16 (Jund). Szpirer, C., Tissir, F., Rivière, M., Levan, G., Szpirer, J. Mamm. Genome (1994) [Pubmed]

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JUND	Bos taurus
JUND	Canis lupus familiaris
jund	Danio rerio
Jund	Mus musculus
Jund	Rattus norvegicus
jund	Xenopus (Silurana) tropicalis

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