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Gene Review

PDE4C  -  phosphodiesterase 4C, cAMP-specific

Homo sapiens

Synonyms: DPDE1, PDE21, cAMP-specific 3',5'-cyclic phosphodiesterase 4C
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Disease relevance of PDE4C


High impact information on PDE4C


Biological context of PDE4C

  • Analysis of this locus indicated that the PDE4C gene spans at least 38 kb, consists of at least 18 exons, and contains the marker D19S212 within an intron [7].
  • Overlapping cosmid clones spanning the human PDE4C gene were identified and characterised [7].
  • Fluorescent in situ hybridisation localised PDE4C to the p13.1 region of human chromosome 19 [7].
  • The longest open reading frame (ORF) of 791 amino acids (aa) is encoded by PDE4C-791, which is similar to a recently described cDNA [Engels, P., Sullivan, M., Muller, T. and Lubbert, H. FEBS Lett. 358 (1995) 305-10], except that an alternative 5'-end sequence upstream of the first methionine extends the PDE4C-791 ORF by 79 aa [2].

Anatomical context of PDE4C


Associations of PDE4C with chemical compounds

  • PDE4C is one of four mammalian genes that encode multiple PDE4 cyclic AMP-specific phosphodiesterase isoforms that are inhibited by rolipram [7].
  • The predicted 426 aa protein initiates at a methionine 365 aa within PDE4C-791 [2].
  • To elucidate further the possible biochemical mechanisms associated with these alterations, we analyzed the phosphorous metabolites by MR spectroscopy and found that the major metabolites were PME, (PC, PE) and DPDE (UDP-GalNAc, UDP-GLcNAc) [12].

Other interactions of PDE4C

  • PDE4A and PDE4B mRNAs also are markedly abundant, whereas lower expression is observed for PDE4C mRNAs [13].


  1. The role of PDE4 in pulmonary inflammation and goblet cell hyperplasia in allergic rats. Tang, H.F., Chen, J.Q., Xie, Q.M., Zheng, X.Y., Zhu, Y.L., Adcock, I., Wang, X. Biochim. Biophys. Acta (2006) [Pubmed]
  2. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. Obernolte, R., Ratzliff, J., Baecker, P.A., Daniels, D.V., Zuppan, P., Jarnagin, K., Shelton, E.R. Biochim. Biophys. Acta (1997) [Pubmed]
  3. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Bolger, G., Michaeli, T., Martins, T., St John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M., Ferguson, K. Mol. Cell. Biol. (1993) [Pubmed]
  4. Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells. Bartsch, O., Bartlick, B., Ivell, R. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  5. Growth of a human colonic adenocarcinoma cell line (HT 29) on microcarrier beads: metabolic studies by 31phosphorus nuclear magnetic resonance spectroscopy. Fantini, J., Galons, J.P., Marvaldi, J., Cozzone, P.J., Canioni, P. Int. J. Cancer (1987) [Pubmed]
  6. Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. Barber, R., Baillie, G.S., Bergmann, R., Shepherd, M.C., Sepper, R., Houslay, M.D., Heeke, G.V. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  7. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. Sullivan, M., Olsen, A.S., Houslay, M.D. Cell. Signal. (1999) [Pubmed]
  8. Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain. Pérez-Torres, S., Miró, X., Palacios, J.M., Cortés, R., Puigdoménech, P., Mengod, G. J. Chem. Neuroanat. (2000) [Pubmed]
  9. Molecular cloning and expression of a human phosphodiesterase 4C. Owens, R.J., Lumb, S., Rees-Milton, K., Russell, A., Baldock, D., Lang, V., Crabbe, T., Ballesteros, M., Perry, M.J. Cell. Signal. (1997) [Pubmed]
  10. Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. Essayan, D.M., Kagey-Sobotka, A., Lichtenstein, L.M., Huang, S.K. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  11. Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Lamontagne, S., Meadows, E., Luk, P., Normandin, D., Muise, E., Boulet, L., Pon, D.J., Robichaud, A., Robertson, G.S., Metters, K.M., Nantel, F. Brain Res. (2001) [Pubmed]
  12. 13-cis-retinoic acid-mediated growth inhibition of DU-145 human prostate cancer cells. Dahiya, R., Boyle, B., Park, H.D., Kurhanewicz, J., Macdonald, J.M., Narayan, P. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  13. Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium. Leroy, M.J., Méhats, C., Duc-Goiran, P., Tanguy, G., Robert, B., Dallot, E., Mignot, T.M., Grangé, G., Ferré, F. Cell. Signal. (1999) [Pubmed]
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