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RAB3A  -  RAB3A, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-3A
 
 
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Psychiatry related information on RAB3A

  • In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population [1].
 

High impact information on RAB3A

  • PDE4C-containing cosmids also contained the genes for the growth regulatory transcription factor, JUND, and the mini guanine nucleotide regulatory protein, RAB3A [2].
  • To investigate the possible genetic contribution of the RAB3A gene, we performed a case-control association study focused on the Han population of northwestern China using four common SNPs in the gene (rs7259012, rs17683539, rs2271882, and rs874628) [1].
  • RAB3A, a Ras-related GTP-binding protein, is found in a rat neuronal cytosol in the form of complex with RabGDI or located on the synaptic vesicles and it cycles between the cytosol and the membranes [3].
 

Biological context of RAB3A

 

Associations of RAB3A with chemical compounds

  • Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND [2].

References

  1. Variants in the RAB3A gene are not associated with mental retardation in the Chinese population. Sun, Y., Zhang, F., Gao, J., Gao, X., Guo, T., Shi, Y., Tang, W., Li, S., Zheng, Z., Zheng, Y., Li, X., Feng, G., He, L. Neurosci. Lett. (2006) [Pubmed]
  2. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. Sullivan, M., Olsen, A.S., Houslay, M.D. Cell. Signal. (1999) [Pubmed]
  3. Phosphatidic acid is important to the translocation of Rab3A from the cytosol to phospholipid membranes. Jung, Y.J., Lee, T.H., Lee, J.Y., Kim, J.H., Park, J.B. Neuroreport (1999) [Pubmed]
 
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