High impact information on vegf-A

• VEGF expression is found in tissues adjacent to the mesenchyme containing the flk-1-expressing endothelial precursors [1].
• When VEGF is expressed ectopically in Xenopus embryos by microinjection of either plasmid DNA or synthetic mRNA, large, disorganized vascular structures are produced [1].
• The Xenopus homologues of flk-1 and VEGF have been cloned and their expression has been examined throughout early embryonic development [1].
• The effect of VEGF on blood vessels and blood cells during Xenopus development [2].
• This study suggests that VEGF has additional biological activities besides angiogenesis, and arises a different function that VEGF induces stroma cell migration or recruitment that are required for blood vessel formation [3].

Anatomical context of vegf-A

• A vascular endothelial growth factor (VEGF) is a powerful mitogen for endothelial cells and is an inducer and regulator of angiogenesis [3].

Analytical, diagnostic and therapeutic context of vegf-A

• This histological result was coincident with our reverse transcriptase-polymerase chain reaction analysis that VEGF together with activin A promoted the expression of Xenopus N-CAM and Xenopus brachyury [3].

References