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Gene Review

NRG1  -  neuregulin 1

Gallus gallus

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High impact information on NRG1

  • Our data suggest that members of the ARIA protein family promote the formation and maintenance of chemical synapses and, furthermore, that receptor tyrosine kinases play important roles in this process [1].
  • ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family [1].
  • Recombinant ARIA increases acetylcholine receptor synthesis greater than 3-fold, and it induces tyrosine phosphorylation of a 185 kd muscle protein [1].
  • The ARIA cDNA hybridizes with mRNAs that are expressed in the spinal cord from E4, a time prior to the onset of neuromuscular synapse formation, through adulthood [1].
  • Chicken ARIA is homologous to the rat Neu differentiation factor and human here-gulin, ligands for the receptor tyrosine kinase encoded by the neu (c-erbB2, HER2) proto-oncogene [1].

Biological context of NRG1


Anatomical context of NRG1


Associations of NRG1 with chemical compounds

  • The activity of neuregulin in the conditioned medium of NG108-15 cells was reduced by treating the medium with heparin and anti-neuregulin antibody [2].

Other interactions of NRG1

  • Even a muscle form of agrin that lacks intrinsic clustering activities by itself, significantly enhances neuregulin-induced clustering and insertion of AChRs [3].

Analytical, diagnostic and therapeutic context of NRG1


  1. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Falls, D.L., Rosen, K.M., Corfas, G., Lane, W.S., Fischbach, G.D. Cell (1993) [Pubmed]
  2. NG108-15 cells express neuregulin that induces AChR alpha-subunit synthesis in cultured myotubes. Pun, S., Yang, J.F., Ng, Y.P., Tsim, K.W. FEBS Lett. (1997) [Pubmed]
  3. Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression. Li, Q., Esper, R.M., Loeb, J.A. Mol. Cell. Neurosci. (2004) [Pubmed]
  4. Neuregulin stimulates DNA synthesis in embryonic chick heart cells. Ford, B.D., Loeb, J.A., Fischbach, G.D. Dev. Biol. (1999) [Pubmed]
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