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Gene Review

TLR2-1  -  toll-like receptor 2 type1

Gallus gallus

Synonyms: TLR2, TLR2A, chTLR2
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Disease relevance of TLR2


High impact information on TLR2

  • These results indicated that chTLR type 2 covers two major microbe patterns, lipoproteins and LPS, which are regulated by TLR2 and TLR4 in mammals [2].
  • We used RT-PCR analysis to examine the TLR expression profile on chicken monocytes and demonstrated these cells express chicken TLR2, 3, 4, 6, and 7 [3].
  • Furthermore, TLR2 (a previously thought candidate as LPS signaling molecule) positive cell numbers were higher in K-strain than the GB2 macrophages in one of the two trials with no difference in the intensity of TLR2 expression in either trial [4].

Biological context of TLR2

  • Only chelerythrine, a protein kinase C inhibitor, was found to significantly inhibit oxidative burst stimulated by the TLR2 agonist lipoteichoic acid (LTA) [1].


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