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Gene Review

TLR2  -  toll-like receptor 2

Bos taurus

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High impact information on TLR2

  • Preinfection of bovine MPhi by BVDV resulted in upregulation of TLR2- and TLR4-mediated NO synthesis [1].
  • Thus, the amount of TLR2, TLR3 and TLR4 mRNA transcripts is stable at least under the conditions tested [1].
  • However, NO production induced by TLR2 or TLR4 agonists was strongly modulated either by IFN-gamma costimulation or BVDV preinfection [1].
  • In addition, we will show the expression of TLR mRNA in bovine antigen-presenting cell subsets, summarise the discovery and the critical roles of TLR2 in host defence against Mycobacteria, and provide evidence for a mycobacteria species-specific response of bovine macrophages [2].
  • IL-1, TNF, and TLR2 and TLR4 were greatest (P < 0.05) for Cnt only at day 14 [3].

Anatomical context of TLR2

  • The number of TLR2 copies correlated well with those of TLR4, indicating coordinated regulation of these two PRRs during infection of the udder [4].

Regulatory relationships of TLR2

  • Toll-like receptor 2 expression was enhanced with Both compared to either DEX (P < 0.05) or GH (P < 0.05) and tended to be greater than Cnt expression (P = 0.07) [3].

Other interactions of TLR2


  1. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Franchini, M., Schweizer, M., Mätzener, P., Magkouras, I., Sauter, K.S., Mirkovitch, J., Peterhans, E., Jungi, T.W. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  2. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination? Werling, D., Piercy, J., Coffey, T.J. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  3. Toll-like receptors 2 and 4, and acute phase cytokine gene expression in dexamethasone and growth hormone treated dairy calves. Eicher, S.D., McMunn, K.A., Hammon, H.M., Donkin, S.S. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  4. Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Goldammer, T., Zerbe, H., Molenaar, A., Schuberth, H.J., Brunner, R.M., Kata, S.R., Seyfert, H.M. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
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