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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IRF4  -  interferon regulatory factor 4

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Disease relevance of IRF4

  • The expression of IRF-4 from retrovirus vectors morphologically transformed primary fibroblasts, increased their saturation density, proliferation, and life span, and promoted their growth in soft agar [1].
 

High impact information on IRF4

  • IRF-10 is most closely related to IRF-4 but differs in both its constitutive and inducible expression [2].
  • The exogenous expression of IRF-4 in v-Rel-transformed fibroblasts decreased the production of IFN1 and suppressed the expression of several genes in the IFN transduction pathway [1].
  • The expression of IRF-4 antisense RNA eliminated formation of soft agar colonies by v-Rel and reduced the proliferation of v-Rel-transformed cells. v-Rel-transformed fibroblasts produced interferon 1 (IFN1), which inhibits fibroblast proliferation [1].
  • IRF-4DeltaE6 mRNA, though less abundant than full-length IRF-4, was detected in lymphoid tissues, with the highest levels observed in thymic cells [1].
  • IRF-4 is highly expressed in v-Rel-transformed lymphocytes, and the expression of IRF-4 is increased in v-Rel- and c-Rel-transformed fibroblasts relative to control cells [1].
 

Biological context of IRF4

 

Anatomical context of IRF4

References

  1. Interferon regulatory factor 4 contributes to transformation of v-Rel-expressing fibroblasts. Hrdlicková, R., Nehyba, J., Bose, H.R. Mol. Cell. Biol. (2001) [Pubmed]
  2. A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein. Nehyba, J., Hrdlicková, R., Burnside, J., Bose, H.R. Mol. Cell. Biol. (2002) [Pubmed]
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