Gene Review:
IRF4 - interferon regulatory factor 4
Homo sapiens
Synonyms:
IRF-4, Interferon regulatory factor 4, LSIRF, Lymphocyte-specific interferon regulatory factor, MUM1, ...
- Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Iida, S., Rao, P.H., Butler, M., Corradini, P., Boccadoro, M., Klein, B., Chaganti, R.S., Dalla-Favera, R. Nat. Genet. (1997)
- Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA. Sundram, U., Harvell, J.D., Rouse, R.V., Natkunam, Y. Mod. Pathol. (2003)
- Expression of MUM1/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis. Carbone, A., Gloghini, A., Cozzi, M.R., Capello, D., Steffan, A., Monini, P., De Marco, L., Gaidano, G. Br. J. Haematol. (2000)
- Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia. Imaizumi, Y., Kohno, T., Yamada, Y., Ikeda, S., Tanaka, Y., Tomonaga, M., Matsuyama, T. Jpn. J. Cancer Res. (2001)
- Expression of interferon regulatory factor 4 in chronic myeloid leukemia: correlation with response to interferon alfa therapy. Schmidt, M., Hochhaus, A., König-Merediz, S.A., Brendel, C., Proba, J., Hoppe, G.J., Wittig, B., Ehninger, G., Hehlmann, R., Neubauer, A. J. Clin. Oncol. (2000)
- Transcriptional control of early B cell development. Busslinger, M. Annu. Rev. Immunol. (2004)
- Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Pongubala, J.M., Van Beveren, C., Nagulapalli, S., Klemsz, M.J., McKercher, S.R., Maki, R.A., Atchison, M.L. Science (1993)
- Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. Lehtonen, A., Veckman, V., Nikula, T., Lahesmaa, R., Kinnunen, L., Matikainen, S., Julkunen, I. J. Immunol. (2005)
- Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy. Uranishi, M., Iida, S., Sanda, T., Ishida, T., Tajima, E., Ito, M., Komatsu, H., Inagaki, H., Ueda, R. Leukemia (2005)
- Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages. Marecki, S., Atchison, M.L., Fenton, M.J. J. Immunol. (1999)
- Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. Gupta, S., Jiang, M., Anthony, A., Pernis, A.B. J. Exp. Med. (1999)
- A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Yamagata, T., Nishida, J., Tanaka, S., Sakai, R., Mitani, K., Yoshida, M., Taniguchi, T., Yazaki, Y., Hirai, H. Mol. Cell. Biol. (1996)
- Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25. Grossman, A., Mittrücker, H.W., Nicholl, J., Suzuki, A., Chung, S., Antonio, L., Suggs, S., Sutherland, G.R., Siderovski, D.P., Mak, T.W. Genomics (1996)
- Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes. Sharma, S., Mamane, Y., Grandvaux, N., Bartlett, J., Petropoulos, L., Lin, R., Hiscott, J. AIDS Res. Hum. Retroviruses (2000)
- IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3. Gauzzi, M.C., Purificato, C., Conti, L., Adorini, L., Belardelli, F., Gessani, S. J. Leukoc. Biol. (2005)
- Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region. Ortmann, C.A., Burchert, A., Hölzle, K., Nitsche, A., Wittig, B., Neubauer, A., Schmidt, M. Nucleic Acids Res. (2005)
- Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins. Gupta, S., Anthony, A., Pernis, A.B. J. Immunol. (2001)
- Folding and purification of a recombinantly expressed interferon regulatory factor, IRF-4. Moellering, B.J., Yoshinaga, S.K., Hui, A., Delaney, J.M., Hara, S., Narhi, L.O., Westcott, K.R. Protein Expr. Purif. (1999)
- Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4. Yoshida, K., Yamamoto, K., Kohno, T., Hironaka, N., Yasui, K., Kojima, C., Mukae, H., Kadota, J., Suzuki, S., Honma, K., Kohno, S., Matsuyama, T. Int. Immunol. (2005)
- Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Sciammas, R., Shaffer, A.L., Schatz, J.H., Zhao, H., Staudt, L.M., Singh, H. Immunity (2006)
- Pathobiology of primary mediastinal B-cell lymphoma. Pileri, S.A., Zinzani, P.L., Gaidano, G., Falini, B., Gaulard, P., Zucca, E., Sabattini, E., Ascani, S., Rossi, M., Cavalli, F. Leuk. Lymphoma (2003)
- Interphase detection of t(4;14)(p16.3;q32.3) by in situ hybridization and FGFR3 overexpression in plasma cell malignancies. Nakazawa, N., Nishida, K., Tamura, A., Kobayashi, M., Iwai, T., Horiike, S., Nishigaki, H., Otsuki, T., Tomiyama, Y., Fujii, H., Kashima, K., Taniwaki, M. Cancer Genet. Cytogenet. (2000)
- Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma. Tamura, A., Miura, I., Iida, S., Yokota, S., Horiike, S., Nishida, K., Fujii, H., Nakamura, S., Seto, M., Ueda, R., Taniwaki, M. Cancer Genet. Cytogenet. (2001)