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Gene Review:

Gp150 - CG5820 gene product from transcript CG5820-RC

Drosophila melanogaster

Synonyms: CG5820, CT18251, Dmel\CG5820, GP150, anon-EST:fe2A1, ...

Fetchko, M. et al., Dhulkotia, D. et al., Li, Y. et al.

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High impact information on Gp150

Genetic analyses suggest that Gp150 functions to modulate Notch signaling [1].
Consistent with this notion, Gp150 is co-localized with Delta in intracellular vesicles in cells within the MF region and loss of gp150 function causes accumulation of intracellular Delta protein [1].
Here we report that the Drosophila leucine-rich repeat transmembrane glycoprotein Gp150 is required for viability, fertility and development of the eye, wing and sensory organs [1].
Gp150 concentrated Sca protein in late endosomes [2].
Gp150 is a transmembrane glycoprotein belonging to the leucine-rich repeat (LRR) superfamily [3].

Biological context of Gp150

Therefore, Gp150 might function in intracellular vesicles to modulate Delta-Notch signaling for cell fate control and tissue morphogenesis [1].
Thus, Gp150 defines a new subfamily of LRR proteins and may be involved in signal transduction [3].

Associations of Gp150 with chemical compounds

Sequence analysis revealed high conservation in the LRRs and cysteine motifs flanking the LRR region in the extracellular domain of Gp150 [3].

Regulatory relationships of Gp150

Scabrous and Gp150 are endosomal proteins that regulate Notch activity [2].

References

Drosophila Gp150 is required for early ommatidial development through modulation of Notch signaling. Fetchko, M., Huang, W., Li, Y., Lai, Z.C. EMBO J. (2002) [Pubmed]
Scabrous and Gp150 are endosomal proteins that regulate Notch activity. Li, Y., Fetchko, M., Lai, Z.C., Baker, N.E. Development (2003) [Pubmed]
Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia, D., Nguyen, D., Lai, Z.C. Dev. Genes Evol. (2000) [Pubmed]

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