High impact information on Adhr

• The dicistronic transcript is found in polysomes and the Adhr protein product is detected by antibody staining [1].
• Codon bias in Adh and Adhr was comparable and found to be very low compared with other species [2].
• The sequence of this genomic region reveals a 2.9-kb tandem duplication which encompasses 1.6 kb of the 5' flanking region, the entire Adh gene, and two thirds of the first exon of the Adhr gene in D. funebris [3].
• The relationship between third-codon position nucleotide content, codon bias, mRNA secondary structure and gene expression in the drosophilid alcohol dehydrogenase genes Adh and Adhr [4].
• Eight of 404 single nucleotide polymorphisms (SNPs) in the Adh region were in significant linkage disequilibrium with three ADHR protein alleles [5].

Biological context of Adhr

• The nucleotide sequences of the Adh and Adhr genes of Drosophila kuntzei were derived from combined overlapping sequences of clones isolated from a genomic library and from cloned PCR and inverse-PCR fragments [2].
• To gain insights into the relationship between codon bias, mRNA secondary structure, third-codon position nucleotide distribution, and gene expression, we predicted secondary structures in two related drosophilid genes, Adh and Adhr, which differ in degree of codon bias and level of gene expression [4].
• This comprises the Adh coding region and introns, 3' UTR, intergenic sequence, and most of Adhr, which is 260 bp downstream of Adh [6].
• The Adh-related gene encodes 18 protein haplotypes and fails to reject an equilibrium neutral model [5].
• Protein variation in Adh and Adh-related in Drosophila pseudoobscura. Linkage disequilibrium between single nucleotide polymorphisms and protein alleles [5].

Other interactions of Adhr

• D. dunni's Adh has the lowest codon bias reported so far for Drosophila species, and based on analysis of the nucleotide substitution rate, it is less conserved than Adhr [6].

Analytical, diagnostic and therapeutic context of Adhr

• Hybridizing the same Northern blots with a specific probe for Adh-dup, we did not find transcripts for this gene in D. lebanonensis [7].

References