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Gene Review:

Mlp60A - Muscle LIM protein at 60A

Drosophila melanogaster

Synonyms: BcDNA:RE14544, BcDNA:RH74176, CG30174, CG30179, CG3220, ...

Stronach, B.E. et al., Keller, C.A. et al., Stronach, B.E. et al.

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High impact information on Mlp60A

Within the somatic musculature, Mlp84B transcripts are enriched at the terminal ends of muscle fibers, whereas Mlp60A transcripts are found throughout the muscle fibers [1].
Mlp60A encodes a protein with a single LIM domain linked to a glycine-rich region [1].
The temporal expression and spatial distribution of muscle LIM proteins in Drosophila are consistent with a role for Mlps in myogenesis, late in the differentiation pathway [1].
Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis [2].
Moreover, many cardioblasts express increased levels of muscle-specific genes such as myosin, actin 57B, and Mlp60A, a protein that is restricted to the somatic, visceral, and pharyngeal muscles [3].

References

Two muscle-specific LIM proteins in Drosophila. Stronach, B.E., Siegrist, S.E., Beckerle, M.C. J. Cell Biol. (1996) [Pubmed]
Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Stronach, B.E., Renfranz, P.J., Lilly, B., Beckerle, M.C. Mol. Biol. Cell (1999) [Pubmed]
Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers. Keller, C.A., Erickson, M.S., Abmayr, S.M. Dev. Biol. (1997) [Pubmed]

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