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Gene Review

Csrp3  -  cysteine and glycine-rich protein 3...

Rattus norvegicus

Synonyms: CRP3, Clp, Cysteine and glycine-rich protein 3, Cysteine-rich protein 3, LIM domain protein, cardiac, ...
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Disease relevance of Csrp3


High impact information on Csrp3

  • The functional form of ClpP, the proteolytic component of ATP-dependent Clp proteases, is a hollow-cored particle composed of two heptameric rings joined face-to-face forming an aqueous chamber containing the proteolytic active sites [4].
  • To identify possible virus-specific contributions to the observed variability in disease outcome, the genomes of CRP3 and CRNP5 were sequenced [5].
  • Compared to rats inoculated with CRP3, adult and newborn Lewis rats inoculated with CRNP5 had more severe and rapidly fatal neurological disease, with increased damage to the hippocampal pyramidal neurons and rapid infection of brain stem neurons [5].
  • Those neuronal profiles that demonstrated muscle LIM protein hybridization were distributed across the profile size range, whereas the distribution of acidic epididymal glycoprotein-positive profiles appeared to be skewed towards smaller profiles [6].
  • The combination of C-ANF4-23 and candoxatrilat again produced a substantial increase in T1/2 beta (153%) and decreases in Vd (55%) and Clp (78%) in nephrectomized animals, although these changes could not be distinguished from those seen in intact animals treated with the same combination [7].

Biological context of Csrp3

  • Similar plasma kinetics and organ distribution for native lysozyme and the drug conjugate were observed (Clp = 1.2 and 1.1 ml/min; t1/2,beta = 85 and 75 min, respectively) [8].
  • This value, when converted to plasma clearance, Clp/F, (0.807 +/- 0.100 mL/min/100 gm, n = 13), was within the range of values reported for the glomerular filtration rate (GFR) in rats (range 0.55 to 1.2 mL/min/100 gm body weight) [9].
  • Conversely, overexpression of MLP augmented cell size and sarcomere organization in cardiac myocytes [3].

Anatomical context of Csrp3


Associations of Csrp3 with chemical compounds

  • Plasma t1/2 was longer and Clp as well as Vd of salicylate were smaller in adult females than in males of comparable age [1].
  • The decreased Clp of ouabain in rats with ARF may come from reduced tissue binding and a concomitant decrease in its volume of distribution (Vd) [11].
  • The rate of equilibration between the maternal and fetal compartments and placental clearance were lower for PABA than for AP (kequilibration = 0.011 and 0.020 min-1; Clp = 0.22 and 0.33 ml/min, respectively); the feto-maternal concentration ratios at equilibrium (FMCReq) were, however, mutually comparable [12].

Analytical, diagnostic and therapeutic context of Csrp3


  1. Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats. Varma, D.R., Yue, T.L. Br. J. Pharmacol. (1984) [Pubmed]
  2. Pharmacokinetics of nizatidine in dogs and rats. Sano, H., Sato, H., Furuta, S., Mogi, M., Matsuki, Y., Motogi, M. Xenobiotica (1991) [Pubmed]
  3. Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy. Heineke, J., Kempf, T., Kraft, T., Hilfiker, A., Morawietz, H., Scheubel, R.J., Caroni, P., Lohmann, S.M., Drexler, H., Wollert, K.C. Circulation (2003) [Pubmed]
  4. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. Kang, S.G., Dimitrova, M.N., Ortega, J., Ginsburg, A., Maurizi, M.R. J. Biol. Chem. (2005) [Pubmed]
  5. Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes. Nishino, Y., Kobasa, D., Rubin, S.A., Pletnikov, M.V., Carbone, K.M. J. Virol. (2002) [Pubmed]
  6. Identification of differentially expressed genes in dorsal root ganglia following partial sciatic nerve injury. Newton, R.A., Bingham, S., Davey, P.D., Medhurst, A.D., Piercy, V., Raval, P., Parsons, A.A., Sanger, G.J., Case, C.P., Lawson, S.N. Neuroscience (2000) [Pubmed]
  7. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade. Barclay, P.L., Bennett, J.A., Greengrass, P.M., Griffin, A., Samuels, G.M., Shepperson, N.B. Biochem. Pharmacol. (1992) [Pubmed]
  8. Low molecular weight proteins as carriers for renal drug targeting: naproxen-lysozyme. Franssen, E.J., van Amsterdam, R.G., Visser, J., Moolenaar, F., de Zeeuw, D., Meijer, D.K. Pharm. Res. (1991) [Pubmed]
  9. Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix. Johnston, T.P., Miller, S.C. Journal of parenteral science and technology : a publication of the Parenteral Drug Association. (1989) [Pubmed]
  10. Muscle LIM protein: expressed in slow muscle and induced in fast muscle by enhanced contractile activity. Schneider, A.G., Sultan, K.R., Pette, D. Am. J. Physiol. (1999) [Pubmed]
  11. Pharmacokinetics and biliary excretion of bromosulphophthalein, [3H]-ouabain and [3H]-taurocholic acid in rats with glycerol-induced acute renal failure. Bowmer, C.J., Yates, M.S. Br. J. Pharmacol. (1984) [Pubmed]
  12. Pharmacokinetic examination of p-aminobenzoic acid passage through the placenta and the small intestine in rats. Staud, F., Fendrich, Z., Jindrová, O., Láznícek, M. Journal of drug targeting. (1997) [Pubmed]
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