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Gene Review

hnf1a-a  -  HNF1 homeobox A

Xenopus laevis

Synonyms: HNF1, LFB1a1, XLFB1, XLFB1b, hnf1-a, ...
 
 
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High impact information on tcf1-A

  • The transcription factor LFB1 (HNF1) was initially identified as a regulator of liver-specific gene expression in mammals [1].
  • Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis [1].
  • The transcription factor LFB1 (HNF1) involved in the expression of liver-specific genes is characterized by a serine/threonine-rich activation domain whose transactivation potential differs between mammals and Xenopus [2].
  • Specific point mutations in the HNF-1-binding site, in a construct containing a wild-type GRE, reduced promoter activity by a factor of 10, while stimulation by glucocorticoids was retained [3].
  • The regulatory region also has a sequence similar to the binding site for a liver-specific transcription factor, hepatocyte nuclear factor 1 (HNF-1), at positions -120 to -132 [3].
 

Biological context of tcf1-A

  • We present evidence suggesting that the mesoderm-inducing factor activin A plays a critical role by acting through the HNF4 binding site of the HNF1 alpha promoter [4].
  • Patterning the expression of a tissue-specific transcription factor in embryogenesis: HNF1 alpha gene activation during Xenopus development [4].
 

Anatomical context of tcf1-A

  • DCoH, the dimerization cofactor of the HNF-1 homeodomain proteins (hepatocyte nuclear factor-1alpha and beta), is involved in gene expression by associating with these transcription factors [5].
  • It is also found in cells lacking HNF1 and PAH like skin, brain and the pigmented epithelium of the eye suggesting a yet unknown function [5].

References

 
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