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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KCNS1  -  potassium voltage-gated channel, modifier...

Homo sapiens

Synonyms: Delayed-rectifier K(+) channel alpha subunit 1, Kv9.1, Potassium voltage-gated channel subfamily S member 1, Voltage-gated potassium channel subunit Kv9.1
 
 
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High impact information on KCNS1

  • Radical anions, Br2- and (CNS)2-, generated by the irradiation of N2O-saturated inhibitor solutions containing KBr or KCNS, reduced tyrosyl CD without affecting disulfide CD bands, indicating that the radical anions damaged Tyr 69 without altering protein conformation [1].
  • All of REST genes reported thus far for human and Muridae were mapped in a chromosomal locus between KCNS1 and SLPI suggesting the locus as an active evolving region [2].
  • We have found that Kv9.1 isolated from a rat brain cDNA library alters the kinetics and the voltage-dependence of activation and inactivation of Kv2.1, a channel subunit that generates slowly inactivating delayed rectifier potassium currents [3].
  • The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety of neurons, including those of the inferior colliculus [3].
  • FIP is insoluble in 2% SDS in 6 M urea, 10 mM Ca2+Ac2, 100% acetic acid, chloroform/methanol (2/1), saturated KCNS, and even 100% trifluoroacetic acid [4].
 

Anatomical context of KCNS1

  • Protease activity was detected in membranes of human bovine erythrocytes prepared by the conventional procedures which include washing and removal of the "buffy layer". The enzyme was extracted by 0.75 M KCNS or (NH4)2SO4 and was activated by 0.4 to 0.5 M of the same salts [5].

References

  1. Lima bean proteinase inhibitor. Origins of circular dichroism bands and modification by Br2- and (CNS)2-. Kay, E., Gumbiner, B. J. Biol. Chem. (1979) [Pubmed]
  2. Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42. Lin, H.J., Lee, C.M., Luo, C.W., Chen, Y.H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. Richardson, F.C., Kaczmarek, L.K. Hear. Res. (2000) [Pubmed]
  4. Ependymin, a brain extracellular glycoprotein, and CNS plasticity. Shashoua, V.E. Ann. N. Y. Acad. Sci. (1991) [Pubmed]
  5. Membrane-bound enzymes. III. Protease activity in leucocytes in relation to erythrocyte membranes. Heller, M., Edelstein, P., Mayer, M. Biochim. Biophys. Acta (1975) [Pubmed]
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