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Gene Review

FRRS1  -  ferric-chelate reductase 1

Homo sapiens

Synonyms: Ferric-chelate reductase 1, SDFR2, SDR-2, SDR2, Stromal cell-derived receptor 2
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High impact information on FRRS1

  • Fe deficiency decreased markedly the FC-R activity per protoplast surface unit [1].
  • These findings imply that induction of FCR and PEPC activities in roots in response to Fe deficiency are important physiological adaptations enabling Fe-efficient kiwifruit plants to tolerate Fe deficiency [2].
  • In response to Fe deficiency, the tolerant genotype D1 showed: (i) higher FCR activity associated with a longer lasting induction of FCR; (ii) higher PEPC activity; (iii) higher concentrations of citric acid in roots; and (iv) lower xylem sap pH compared with the susceptible genotype Hayward [2].
  • Seedlings grown without Fe developed some responses typical of the Strategy I group of Fe-efficient plants, including two- and fourfold increases in plasma membrane ferric chelate reductase activity of root tips after 2 and 4 weeks of culture in the absence of Fe, respectively [3].
  • Both soluble ferric chelate reductase isoforms are strongly inhibited by p-hydroxymercuribenzoic acid (I50 5 nM) and by cibachron blue, the latter giving nonlinear inhibition [4].

Biological context of FRRS1

  • On 4 chromosomes, we detected 5 putative segregation distortion regions (SDRs), including 2 new ones (SDR2 and SDR7) [5].

Anatomical context of FRRS1

  • Furthermore, we show that the rat sdr2 message is predominantly expressed in the liver and kidney, with low expression in the duodenum [6].
  • Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis [6].

Associations of FRRS1 with chemical compounds


  1. Iron deficiency decreases the Fe(III)-chelate reducing activity of leaf protoplasts. González-Vallejo, E.B., Morales, F., Cistué, L., Abadía, A., Abadía, J. Plant Physiol. (2000) [Pubmed]
  2. Biochemical responses to iron deficiency in kiwifruit (Actinidia deliciosa). Rombolà, A.D., Brüggemann, W., López-Millán, A.F., Tagliavini, M., Abadía, J., Marangoni, B., Moog, P.R. Tree Physiol. (2002) [Pubmed]
  3. Characterization of the responses of cork oak (Quercus suber) to iron deficiency. Gogorcena, Y., Molias, N., Larbi, A., Abadía, J., Abadía, A. Tree Physiol. (2001) [Pubmed]
  4. Characterization of a novel NADH-specific, FAD-containing, soluble reductase with ferric citrate reductase activity from maize seedlings. Sparla, F., Preger, V., Pupillo, P., Trost, P. Arch. Biochem. Biophys. (1999) [Pubmed]
  5. QTL mapping of Fusarium moniliforme ear rot resistance in maize. 1. Map construction with microsatellite and AFLP markers. Zhang, F., Wan, X.Q., Pan, G.T. J. Appl. Genet. (2006) [Pubmed]
  6. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas, J.D., Herpers, B., McKie, A.T., Gledhill, S., McDonnell, J., van den Heuvel, M., Davies, K.E., Ponting, C.P. Biochim. Biophys. Acta (2003) [Pubmed]
  7. Effect of ammonium and nitrate on ferric chelate reductase and nitrate reductase in Vaccinium species. Poonnachit, U., Darnell, R. Ann. Bot. (2004) [Pubmed]
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