High impact information on eyg

• In humans and mice, the sole PAX6 gene produces the isoform PAX6(5a) by alternative splicing; like Eyegone, this isoform binds DNA though the C terminus of the paired domain [1].
• It is unique among Pax proteins, because it contains only the RED domain. eyg seems to play a role both in the organogenesis of the salivary gland during embryogenesis and in the development of the eye [2].
• Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye [3].
• In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation [3].
• In the absence of eyg function the anterior-central region does not develop, whereas ectopic activity of either eyg or toe induces the formation of the anterior-central pattern in the posterior or lateral region of the notum [4].

Biological context of eyg

• Our results also show that eyg has two major functions: to promote cell proliferation in the eye disc and to promote eye development through suppression of wg transcription [5].

Anatomical context of eyg

• The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila [4].

Regulatory relationships of eyg

• decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc [6].

Other interactions of eyg

• We report the identification of a Drosophila Pax gene, eye gone (eyg), which is required for eye development [5].
• We show that eyg and its related gene, twin of eyegone (toe), are also expressed in part of the anterior compartment of the adult mesothorax (notum) [4].
• We show that both eyes absent and eyegone are required for normal activation of decapentaplegic expression at the posterior and lateral margins of the disc, and repression of wingless expression in presumptive retinal tissue [6].

References