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irs2  -  insulin receptor substrate 2

Xenopus (Silurana) tropicalis

Synonyms: irs1, irsu
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High impact information on irs1


Biological context of irs1


Associations of irs1 with chemical compounds


  1. Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation. Liu, X.J., Sorisky, A., Zhu, L., Pawson, T. Mol. Cell. Biol. (1995) [Pubmed]
  2. A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling. Farah, S., Agazie, Y., Ohan, N., Ngsee, J.K., Liu, X.J. J. Biol. Chem. (1998) [Pubmed]
  3. Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes. Yamamoto-Honda, R., Honda, Z., Ueki, K., Tobe, K., Kaburagi, Y., Takahashi, Y., Tamemoto, H., Suzuki, T., Itoh, K., Akanuma, Y., Yazaki, Y., Kadowaki, T. J. Biol. Chem. (1996) [Pubmed]
  4. The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Myers, M.G., White, M.F. Diabetes (1993) [Pubmed]
  5. Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. Chuang, L.M., Hausdorff, S.F., Myers, M.G., White, M.F., Birnbaum, M.J., Kahn, C.R. J. Biol. Chem. (1994) [Pubmed]
  6. RHO-associated protein kinase alpha potentiates insulin-induced MAP kinase activation in Xenopus oocytes. Ohan, N., Agazie, Y., Cummings, C., Booth, R., Bayaa, M., Liu, X.J. J. Cell. Sci. (1999) [Pubmed]
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