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Gene Review

pik3r1-a  -  phosphoinositide-3-kinase

Xenopus laevis

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High impact information on PIK3R1


Biological context of PIK3R1


Anatomical context of PIK3R1

  • Pretreatment of these oocytes with wortmannin inhibited insulin-induced activation of PI 3-kinase in vivo [10].
  • We find that a class 1A PI3K catalytic activity is required for the definition of trunk mesoderm during the blastula stages, but is less important for endoderm and prechordal plate mesoderm induction or for organiser formation [11].
  • These results indicate that alphaPIX is activated by PI3-kinase, and is involved in the receptor mediated signaling leading to the activation of the kinase activity of PAK, and the migration of mesodermal cells on extracellular matrix [12].
  • However, our analysis of these pathways in gastrula stage embryos indicates that the MAP kinase pathway is required for Cdx gene expression, whereas the PI-3 kinase pathway is not [13].
  • These data suggest that SGK is a PI3K-dependent integrator of insulin and mineralocorticoid actions that interacts with ENaC subunits to control Na+ entry into kidney collecting duct cells [14].

Associations of PIK3R1 with chemical compounds


Other interactions of PIK3R1


Analytical, diagnostic and therapeutic context of PIK3R1


  1. Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Sarkissian, M., Mendez, R., Richter, J.D. Genes Dev. (2004) [Pubmed]
  2. PI-3 kinase and IP3: partners in NT3-induced synaptic transmission. Kaplan, D.R., Cooper, E. Nat. Neurosci. (2001) [Pubmed]
  3. PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Yang, F., He, X., Feng, L., Mizuno, K., Liu, X.W., Russell, J., Xiong, W.C., Lu, B. Nat. Neurosci. (2001) [Pubmed]
  4. Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Ming, G., Song, H., Berninger, B., Inagaki, N., Tessier-Lavigne, M., Poo, M. Neuron (1999) [Pubmed]
  5. Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends. McSherry, T.D., Mueller, P.R. Mol. Cell. Biol. (2004) [Pubmed]
  6. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Wu, J., O'donnell, M., Gitler, A.D., Klein, P.S. Development (2006) [Pubmed]
  7. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Stambolic, V., Ruel, L., Woodgett, J.R. Curr. Biol. (1996) [Pubmed]
  8. Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development. Peng, Y., Jiang, B.H., Yang, P.H., Cao, Z., Shi, X., Lin, M.C., He, M.L., Kung, H.F. J. Biol. Chem. (2004) [Pubmed]
  9. Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes. Gould, G.W., Jess, T.J., Andrews, G.C., Herbst, J.J., Plevin, R.J., Gibbs, E.M. J. Biol. Chem. (1994) [Pubmed]
  10. Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation. Liu, X.J., Sorisky, A., Zhu, L., Pawson, T. Mol. Cell. Biol. (1995) [Pubmed]
  11. Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction. Carballada, R., Yasuo, H., Lemaire, P. Development (2001) [Pubmed]
  12. alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Yoshii, S., Tanaka, M., Otsuki, Y., Wang, D.Y., Guo, R.J., Zhu, Y., Takeda, R., Hanai, H., Kaneko, E., Sugimura, H. Oncogene (1999) [Pubmed]
  13. FGF signal transduction and the regulation of Cdx gene expression. Keenan, I.D., Sharrard, R.M., Isaacs, H.V. Dev. Biol. (2006) [Pubmed]
  14. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Wang, J., Barbry, P., Maiyar, A.C., Rozansky, D.J., Bhargava, A., Leong, M., Firestone, G.L., Pearce, D. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  15. Phosphatidylinositol 3-kinase activity is important for progesterone-induced Xenopus oocyte maturation. Muslin, A.J., Klippel, A., Williams, L.T. Mol. Cell. Biol. (1993) [Pubmed]
  16. A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse. Liou, J.C., Ho, S.Y., Shen, M.R., Liao, Y.P., Chiu, W.T., Kang, K.H. J. Cell. Sci. (2005) [Pubmed]
  17. Functional interactions between isolated SH2 domains and insulin/Ras signaling pathways of Xenopus oocytes: opposite effects of the carboxy- and amino-terminal SH2 domains of p85 PI 3-kinase. Aroca, P., Mahadevan, D., Santos, E. Oncogene (1996) [Pubmed]
  18. Contribution of JNK, Mek, Mos and PI-3K signaling to GVBD in Xenopus oocytes. Mood, K., Bong, Y.S., Lee, H.S., Ishimura, A., Daar, I.O. Cell. Signal. (2004) [Pubmed]
  19. Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. Fraser, C.S., Pain, V.M., Morley, S.J. Biochem. J. (1999) [Pubmed]
  20. Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase. Kim, J.H., Lim, Y.J., Ro, Y.J., Min, S.W., Kim, C.S., Do, S.H., Kim, Y.L., Zuo, Z. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  21. Deciphering the H-Ras pathway in Xenopus oocyte. Gaffré, M., Dupré, A., Valuckaite, R., Suziedelis, K., Jessus, C., Haccard, O. Oncogene (2006) [Pubmed]
  22. Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers. Markadieu, N., Crutzen, R., Blero, D., Erneux, C., Beauwens, R. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
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