High impact information on trn

• Here, we present evidence that two transmembrane proteins with leucine-rich repeats, known as Capricious and Tartan, contribute to formation of the affinity boundary between dorsal and ventral compartments during Drosophila wing development [1].
• The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing [1].
• Whereas genes such as phyllopod play a crucial role during specification of particular muscles, others such as tartan are necessary for normal muscle morphogenesis [2].
• These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan [3].
• Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis [4].

Biological context of trn

• We present evidence showing that cells incorrectly specified for their position undergo apoptosis because they fail to express specific proteins that are found on surrounding cells, including the LRR transmembrane proteins Capricious and Tartan [5].

Anatomical context of trn

• The LRR transmembrane proteins Capricious and Tartan are transiently expressed in D cells and contribute to initial segregation of D and V cells [6].
• Mutants homozygous for a recessive lethal tartan loss-function allele exhibit defects in the position and number of cells within peripheral sense organs, the routing of peripheral nerves, and the organization of commissures within the central nervous system [7].

Analytical, diagnostic and therapeutic context of trn

• Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan [8].

References