High impact information on caps

• Here, we present evidence that two transmembrane proteins with leucine-rich repeats, known as Capricious and Tartan, contribute to formation of the affinity boundary between dorsal and ventral compartments during Drosophila wing development [1].
• We show here that Capricious (CAPS), a transmembrane protein with leucine-rich repeats (LRRs), is a layer-specific cell adhesion molecule that regulates photoreceptor targeting in the medulla [2].
• Cell lineage: compartments and Capricious [3].
• We propose that Capricious contributes to the instructive role of bridge-cells whereas Tartan provides permissive substrate for the migrating tracheal cells during the network formation [4].
• Our data suggest that the extracellular domains of Capricious and Tartan may work as ligands of an unknown D cell surface protein [5].

Biological context of caps

• We present evidence showing that cells incorrectly specified for their position undergo apoptosis because they fail to express specific proteins that are found on surrounding cells, including the LRR transmembrane proteins Capricious and Tartan [6].
• Interestingly, only the extracellular domains of Capricious and Tartan are required, suggesting that a bidirectional process of cell communication is involved in triggering apoptosis [6].

Anatomical context of caps

• The LRR transmembrane proteins Capricious and Tartan are transiently expressed in D cells and contribute to initial segregation of D and V cells [7].

Associations of caps with chemical compounds

• The leucine-rich repeats transmembrane proteins Capricious and Tartan have been shown to contribute to formation of the affinity boundary between dorsal and ventral compartments [5].

Analytical, diagnostic and therapeutic context of caps

• Boundary formation in the Drosophila wing: functional dissection of Capricious and Tartan [5].

References