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Gene Review:

F2 - coagulation factor II (thrombin)

Gallus gallus

Yazawa, R. et al., Collins, M.S. et al., Lee, Y.J. et al.

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Disease relevance of F2

In a challenge experiment, 65% of the F2 transgenic fish survived an infection of Flavobacterium columnare and 60% survived an infection of Edwardsiella tarda, whereas 100% of the control fish were killed by both pathogens [1].
The lytic activity of protein extracts from the liver (assessed by a lysoplate assay using Micrococcus lysodeikticus as a substrate) was 1.75 times higher in F2 transgenic zebrafish than in the wild type [1].
The amino acid sequence at the F2/F1 cleavage site of the F0 fusion protein of 17 strains of Newcastle disease virus (NDV) was deduced from sequencing a 32 nucleotide area of the genome by reverse transcription and polymerase chain reaction (PCR) techniques [2].

High impact information on F2

All isolates showed the amino acid sequence 112R-R-Q/R-K-R116 at the C-terminus of the F2 protein and phenylalanine (F) at the N-terminus of the F1 protein, residue 117 [3].

References

Transgenic zebrafish expressing chicken lysozyme show resistance against bacterial diseases. Yazawa, R., Hirono, I., Aoki, T. Transgenic Res. (2006) [Pubmed]
Deduced amino acid sequences at the fusion protein cleavage site of Newcastle disease viruses showing variation in antigenicity and pathogenicity. Collins, M.S., Bashiruddin, J.B., Alexander, D.J. Arch. Virol. (1993) [Pubmed]
Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships. Lee, Y.J., Sung, H.W., Choi, J.G., Kim, J.H., Song, C.S. Avian Pathol. (2004) [Pubmed]

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