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FURIN  -  furin (paired basic amino acid cleaving...

Gallus gallus

 
 
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Disease relevance of FURIN

  • Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin [1].
 

High impact information on FURIN

  • Ubiquitous expression of furin and other proprotein convertases in the chick embryo indicated that proteolytic activation of HA was not responsible for restriction of infection to the endothelium [2].
  • Deletion of the insert revealed that the amino acid sequence -1 to -4 predisposes the protein for furin recognition [1].
  • Site-directed mutagenesis of the cleavage site indicated that the arginine in position -4 is critical for HA activation by furin [1].
  • The open reading frame (ORF) of this cDNA encodes a 288-amino acid protein containing a predicted transmembrane domain and a putative furin protease cleavage site like chicken BAFF (cBAFF), human BAFF (hBAFF) and mouse BAFF (mBAFF) [3].
  • Two polyclonal antisera directed against the predicted catalytic domain of furin showed the highest level of immunoreactivity in a microsomal fraction that had minimal proalbumin converting activity [4].
 

Anatomical context of FURIN

  • Rat and chicken liver microsomal membranes were used to investigate the relationship between proalbumin processing activity and the predicted proteinase furin [4].

References

  1. Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin. Morsy, J., Garten, W., Rott, R. Virology (1994) [Pubmed]
  2. Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos. Feldmann, A., Schäfer, M.K., Garten, W., Klenk, H.D. J. Virol. (2000) [Pubmed]
  3. Cloning, expression and bioactivity of duck BAFF. Guan, Z.B., Ye, J.L., Dan, W.B., Yao, W.J., Zhang, S.Q. Mol. Immunol. (2007) [Pubmed]
  4. The predicted proteinase furin is not the hepatic proalbumin convertase. Ledgerwood, E.C., George, P.M., Bathurst, I.C., Brennan, S.O. Biochim. Biophys. Acta (1992) [Pubmed]
 
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