Gene Review:
Furin - furin (paired basic amino acid cleaving...
Rattus norvegicus
Synonyms:
Dibasic-processing enzyme, Fur, PACE, Pace, Paired basic amino acid residue-cleaving enzyme, ...
Wouters,
Leruth,
Decroly,
Vandenbranden,
Creemers,
van de Loo,
Ruysschaert,
Courtoy,
Richt,
Fürbringer,
Koch,
Pfeuffer,
Herden,
Bause-Niedrig,
Garten,
Guo,
Jiang,
Elliott,
Piacentini,
Stawowy,
Margeta,
Kallisch,
Seidah,
Chrétien,
Fleck,
Graf,
Stawowy,
Kallisch,
Kilimnik,
Margeta,
Seidah,
Chrétien,
Fleck,
Graf,
- Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats. Hakes, D.J., Birch, N.P., Mezey, A., Dixon, J.E. Endocrinology (1991)
- Processing of prothyrotropin-releasing hormone by the family of prohormone convertases. Schaner, P., Todd, R.B., Seidah, N.G., Nillni, E.A. J. Biol. Chem. (1997)
- Mechanism of Borna disease virus entry into cells. Gonzalez-Dunia, D., Cubitt, B., de la Torre, J.C. J. Virol. (1998)
- Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus. Walker, J.A., Molloy, S.S., Thomas, G., Sakaguchi, T., Yoshida, T., Chambers, T.M., Kawaoka, Y. J. Virol. (1994)
- Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin. Richt, J.A., Fürbringer, T., Koch, A., Pfeuffer, I., Herden, C., Bause-Niedrig, I., Garten, W. J. Virol. (1998)
- Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation. Dittié, A.S., Thomas, L., Thomas, G., Tooze, S.A. EMBO J. (1997)
- The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system. Bosshart, H., Humphrey, J., Deignan, E., Davidson, J., Drazba, J., Yuan, L., Oorschot, V., Peters, P.J., Bonifacino, J.S. J. Cell Biol. (1994)
- The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity. Zheng, M., Streck, R.D., Scott, R.E., Seidah, N.G., Pintar, J.E. J. Neurosci. (1994)
- Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Bloomquist, B.T., Eipper, B.A., Mains, R.E. Mol. Endocrinol. (1991)
- Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets. Kayo, T., Konda, Y., Tanaka, S., Takata, K., Koizumi, A., Takeuchi, T. Endocrinology (1996)
- Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: effect in vitro and in vivo on rat Leydig (H-500) tumor cells. Liu, B., Amizuka, N., Goltzman, D., Rabbani, S.A. Int. J. Cancer (1995)
- Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro. Stawowy, P., Marcinkiewicz, J., Graf, K., Seidah, N., Chrétien, M., Fleck, E., Marcinkiewicz, M. J. Histochem. Cytochem. (2001)
- Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Stawowy, P., Margeta, C., Kallisch, H., Seidah, N.G., Chrétien, M., Fleck, E., Graf, K. Cardiovasc. Res. (2004)
- Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1. Posner, S.F., Vaslet, C.A., Jurofcik, M., Lee, A., Seidah, N.G., Nillni, E.A. Endocrine (2004)
- Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane. Mayer, G., Boileau, G., Bendayan, M. J. Cell. Sci. (2003)
- Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells. Stawowy, P., Blaschke, F., Kilimnik, A., Goetze, S., Kallisch, H., Chrétien, M., Marcinkiewicz, M., Fleck, E., Graf, K. Hypertension (2002)
- Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments. Wouters, S., Leruth, M., Decroly, E., Vandenbranden, M., Creemers, J.W., van de Loo, J.W., Ruysschaert, J.M., Courtoy, P.J. Biochem. J. (1998)
- Processing of procarboxypeptidase E into carboxypeptidase E occurs in secretory vesicles. Song, L., Fricker, L. J. Neurochem. (1995)
- The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes. Mayer, G., Boileau, G., Bendayan, M. Cell Tissue Res. (2004)
- Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa. Cammisotto, P.G., Gingras, D., Renaud, C., Levy, E., Bendayan, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor. Stawowy, P., Kallisch, H., Kilimnik, A., Margeta, C., Seidah, N.G., Chrétien, M., Fleck, E., Graf, K. Biochem. Biophys. Res. Commun. (2004)
- Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3. Canaff, L., Bennett, H.P., Hou, Y., Seidah, N.G., Hendy, G.N. Endocrinology (1999)
- Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets. Nagamune, H., Muramatsu, K., Akamatsu, T., Tamai, Y., Izumi, K., Tsuji, A., Matsuda, Y. Endocrinology (1995)
- Paradigmatic identification of MMP-2 and MT1-MMP activation systems in cardiac fibroblasts cultured as a monolayer. Guo, C., Jiang, J., Elliott, J.M., Piacentini, L. J. Cell. Biochem. (2005)
- The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation. Gendron, F.P., Mongrain, S., Laprise, P., McMahon, S., Dubois, C.M., Blais, M., Asselin, C., Rivard, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates. Beaubien, G., Schäfer, M.K., Weihe, E., Dong, W., Chrétien, M., Seidah, N.G., Day, R. Cell Tissue Res. (1995)