Disease relevance of ATF2

• In contrast to v-Jun, v-Jun-m1 gave rise to numerous fibrosarcomas while coexpression of ATF2 and v-Jun-m1 led to a dramatic development of fibrosarcomas visible within 1 week [1].

High impact information on ATF2

• Experiments were designed to evaluate a possible role of ATF2 in oncogenesis in chick embryo fibroblasts (CEFs) in the presence or absence of v-Jun [1].
• These results suggest an important role for c-Fos and ATF-2 in glucagon-mediated inhibition of transcription of the malic enzyme gene [2].
• Recent experiments using a fusion protein have shown that E1A can function through a specific CRE (cyclic AMP response element)-binding protein, CRE-BP1 (also designated ATF-2), which stimulates the transcription from a CRE-containing promoter by homodimer formation or heterodimer formation with c-Jun [3].
• Furthermore, okadaic acid caused an increase of the threonine phosphorylation of protein kinase Czeta (PKCzeta) and activator of transcription factor (ATF2) and a decrease of the phosphorylation of Sp1 [4].

Biological context of ATF2

• All these effects were reversed by staurosporine, and TTX also abolished ATF2 phosphorylation [4].

Analytical, diagnostic and therapeutic context of ATF2

• In addition, we examined the role of ATF2 in tumor formation by subcutaneous injection of CEFs into chickens [1].

References