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Gene Review

RAD54L  -  RAD54-like (S. cerevisiae)

Gallus gallus

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Disease relevance of RAD54L


High impact information on RAD54L

  • A RAD54 homolog was disrupted in the chicken B cell line DT40, which undergoes immunoglobulin gene conversion and exhibits unusually high ratios of targeted to random integration after DNA transfection [2].
  • Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line [2].
  • ATM(-/-) cells show altered kinetics of radiation-induced Rad51 and Rad54 focus formation [3].
  • To investigate the distinctive as well as redundant roles of these two repair pathways, we analyzed the mutants RAD54(-/-), KU70(-/-) and RAD54(-/-)/KU70(-/-), generated from the chicken B-cell line DT40 [1].
  • However, caffeine has a much smaller radiosensitizing effect on RAD54(-/-) cells and has no effect on RAD51-deficient cells [4].

Biological context of RAD54L

  • Genetic analyses confirm this suggestion as we have demonstrated an epistatic relationship between 53BP1 and the NHEJ genes, Ku70 and Artemis, but not with Rad54, a gene essential for repair of DSBs by homologous recombination [5].


  1. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A., Takeda, S. EMBO J. (1998) [Pubmed]
  2. Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line. Bezzubova, O., Silbergleit, A., Yamaguchi-Iwai, Y., Takeda, S., Buerstedde, J.M. Cell (1997) [Pubmed]
  3. The controlling role of ATM in homologous recombinational repair of DNA damage. Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K., Takeda, S. EMBO J. (2000) [Pubmed]
  4. Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing. Wang, H., Wang, X., Iliakis, G., Wang, Y. Radiat. Res. (2003) [Pubmed]
  5. Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. Nakamura, K., Sakai, W., Kawamoto, T., Bree, R.T., Lowndes, N.F., Takeda, S., Taniguchi, Y. DNA Repair (Amst.) (2006) [Pubmed]
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